4q6s: Difference between revisions

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'''~~Unreleased structure~~'''

==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36==

~~The entry~~ 4q6s is ~~ON HOLD until Apr 29 2016~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6S FirstGlance].

~~Authors~~: ~~Amacher~~, J.F., ~~Madden~~, D.R.

</td></tr><tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4jof|4jof]]</td></tr>

~~Description~~: ~~CFTR Associated Ligand~~ (~~CAL~~) ~~PDZ bound to biotinylated peptide BT~~-~~L-iCAL36~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [http://www.ebi.ac.uk/pdbsum/4q6s PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

[[Category: Amacher, J.F]]

== Disease ==

[[Category: Madden, D.R]]

[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>

== Function ==

[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Amacher, J F]]

[[Category: Madden, D R]]

[[Category: Pdz-peptide complex]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36==
+<StructureSection load='4q6s' size='340' side='right' caption='[[4q6s]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
-The entry 4q6s is ON HOLD  until Apr 29 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6S FirstGlance]. <br>
-Authors: Amacher, J.F., Madden, D.R.
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jof|4jof]]</td></tr>
-Description: CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [http://www.ebi.ac.uk/pdbsum/4q6s PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Amacher, J.F]]
+== Disease ==
-[[Category: Madden, D.R]]
+[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Amacher, J F]]
+[[Category: Madden, D R]]
+[[Category: Pdz-peptide complex]]
+[[Category: Transport protein]]