4z3k: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite xanthurenic acid==

~~The entry~~ 4z3k is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4z3k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z3K OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z3K FirstGlance].

~~Authors~~: ~~Johnsson~~, K.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=4KL:XANTHURIC+ACID'>4KL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4xwy|4xwy]]</td></tr>

~~Description~~: ~~Human~~ sepiapterin reductase in ~~complex with~~ the ~~cofactor NADP+ and~~ the ~~trypthophan metabolite xanthurenic acid~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Sepiapterin_reductase_(L-erythro-7,8-dihydrobiopterin_forming) Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.153 1.1.1.153] </td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z3k OCA], [http://pdbe.org/4z3k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z3k RCSB], [http://www.ebi.ac.uk/pdbsum/4z3k PDBsum]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:[http://omim.org/entry/612716 612716]]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.<ref>PMID:11443547</ref> <ref>PMID:16650784</ref> <ref>PMID:17159114</ref>

== Function ==

[[http://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

== References ==

__TOC__

</StructureSection>

[[Category: Johnsson, K]]

[[Category: Inhibitor]]

[[Category: Oxidoreductase]]

[[Category: Sepiapterin-reductase]]

[[Category: Tryptophan-metabolite]]

[[Category: Xanthurenic acid]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite xanthurenic acid==
+<StructureSection load='4z3k' size='340' side='right' caption='[[4z3k]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-The entry 4z3k is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4z3k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z3K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z3K FirstGlance]. <br>
-Authors: Johnsson, K.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4KL:XANTHURIC+ACID'>4KL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xwy|4xwy]]</td></tr>
-Description: Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite xanthurenic acid
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sepiapterin_reductase_(L-erythro-7,8-dihydrobiopterin_forming) Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.153 1.1.1.153] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z3k OCA], [http://pdbe.org/4z3k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z3k RCSB], [http://www.ebi.ac.uk/pdbsum/4z3k PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:[http://omim.org/entry/612716 612716]]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.<ref>PMID:11443547</ref> <ref>PMID:16650784</ref> <ref>PMID:17159114</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/SPRE_HUMAN SPRE_HUMAN]] Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Johnsson, K]]
+[[Category: Inhibitor]]
+[[Category: Oxidoreductase]]
+[[Category: Sepiapterin-reductase]]
+[[Category: Tryptophan-metabolite]]
+[[Category: Xanthurenic acid]]