Sandbox Reserved 1057: Difference between revisions
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<scene name='69/694224/Succinate_hydrogen_bonding/1'>succinate hydrogen bonding</scene> | |||
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== Relevance == | == Relevance == | ||
The thiol group on the conserved Cys191 gets deprotonated by His193 residue to make it a better nucleophile that will deprotonate the alcohol on isocitrate. | |||
Mg<sup>2+</sup> is used to stabalize the electrostatic repulsion of two of the three negative charges of the carboxylates. The oxyanion resonates to break a C-C bond forming two products and to force a carbonyl into an oxyanion. On this second product, the oxyanion resonates to form two carboxylates that are stabalized by a Mg ion. | |||
== Structural highlights == | == Structural highlights == | ||
