Sandbox Reserved 1058: Difference between revisions
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===Regulation=== | ===Regulation=== | ||
Isocitrate lyase competes with [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase isocitrate dehydrogenase], an enzyme found in the [http://en.wikipedia.org/wiki/Citric_acid_cycle citric cycle], for isocitrate processing. The favoritism of one enzyme over the other is controlled by the phosphorylation of isocitrate dehydrogenase. This enzyme has a much higher affinity for isocitrate as compared to isocitrate lyase. Phosphorylation of isocitrate dehydrogenase inactivates the enzyme and leades to increased isocitrate lyase activity. <ref name="cozzone"> Cozzone, A.; Regulation of acetate metabolism by protein phosphorylation in enteric bacteria. ''Annual Review of Microbiology''. '''1998''', ''52'':127-164. doi: 10.1146/annurev.micro.52.1.127. </ref> | Isocitrate lyase competes with [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase isocitrate dehydrogenase], an enzyme found in the [http://en.wikipedia.org/wiki/Citric_acid_cycle citric cycle], for isocitrate processing. The favoritism of one enzyme over the other is controlled by the phosphorylation of isocitrate dehydrogenase. This enzyme has a much higher affinity for isocitrate as compared to isocitrate lyase. Phosphorylation of isocitrate dehydrogenase inactivates the enzyme and leades to increased isocitrate lyase activity. <ref name="cozzone"> Cozzone, A.; Regulation of acetate metabolism by protein phosphorylation in enteric bacteria. ''Annual Review of Microbiology''. '''1998''', ''52'':127-164. doi: 10.1146/annurev.micro.52.1.127. </ref> | ||
