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| == Structural highlights == | | == Structural highlights == |
| MbtI structure has a mobile element that can adopt a closed or open conformation depending on whether or not ligands are bound to the active site or not. This loop is made up of the residues 323 to 337 in MbtI.
| | MtI structure has a mobile element (residues 323 to 227) that can adopt a <scene name='69/694235/Irp9_closed_state/2'>closed</scene> or <scene name='69/694235/2g5f_with_open_loop/1'>open conformation</scene> depending on whether or not ligands are bound to the active site. The closed conformation partially obstructs the active site. <ref>PMID:22607697</ref>. |
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| MbtI in the open conformation as seen in the crystal structure<scene name='69/694235/2g5f_with_open_loop/1'>2G5F, the mobile element that adopts the open and closed conformation is colored in grey.</scene> The mobile element is made up of the residues 232 to 337
| | <scene name='69/694235/Irp9_closed_state/2'>closed</scene> |
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| When the enzyme MbtI preforms its function, it undergoes a conformation change between two major forms. These are the open and closed conformations. The closed conformation presents itself when a loop consisting of residues (323 to 337) partially obstructs the active residues. The open conformation occurs when the loop is not partially obstructing the active resides. The conformation change between the open and closed occurs when the ligand binds, with the open position occurring when a ligand is bound to the enzyme <ref>PMID:22607697</ref>.
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| <scene name='69/694235/Irp9_closed_state/2'>TextToBeDisplayed</scene> | |
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| ==Molecular Mechanism== | | ==Molecular Mechanism== |
