2n1b: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 2n1b is ~~ON HOLD until Paper Publication~~

==NMR solution structure of nucleotide-free Ran GTPase==

~~Authors~~: ~~Bacot~~-~~Davis~~, V.R., ~~Palmenberg~~, A.C.

== Structural highlights ==

<table><tr><td colspan='2'>[[2n1b]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N1B FirstGlance]. <br>

~~Description: NMR solution structure of nucleotide-free Ran GTPase~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1b OCA], [http://pdbe.org/2n1b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n1b RCSB], [http://www.ebi.ac.uk/pdbsum/2n1b PDBsum]</span></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

[[Category: Bacot-Davis, V.R]]

== Function ==

[[Category: Palmenberg, A.C]]

[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bacot-Davis, V R]]

[[Category: Palmenberg, A C]]

[[Category: G protein]]

[[Category: Gtp-binding]]

[[Category: Nucleotide-binding]]

[[Category: Nucleus]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 2n1b is ON HOLD  until Paper Publication
+==NMR solution structure of nucleotide-free Ran GTPase==
+<StructureSection load='2n1b' size='340' side='right' caption='[[2n1b]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
-Authors: Bacot-Davis, V.R., Palmenberg, A.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2n1b]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N1B FirstGlance]. <br>
-Description: NMR solution structure of nucleotide-free Ran GTPase
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1b OCA], [http://pdbe.org/2n1b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n1b RCSB], [http://www.ebi.ac.uk/pdbsum/2n1b PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Bacot-Davis, V.R]]
+== Function ==
-[[Category: Palmenberg, A.C]]
+[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>   Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bacot-Davis, V R]]
+[[Category: Palmenberg, A C]]
+[[Category: G protein]]
+[[Category: Gtp-binding]]
+[[Category: Nucleotide-binding]]
+[[Category: Nucleus]]
+[[Category: Transport protein]]