4z8b: Difference between revisions

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'''~~Unreleased structure~~'''

==crystal structure of a DGL mutant - H51G H131N==

~~The entry~~ 4z8b is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4z8b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z8B FirstGlance]. <br>

~~Authors~~: ~~Zamora-Caballero~~, S., ~~Perez~~, A., ~~Sanz~~, L., ~~Bravo~~, J., ~~Calevete, J~~.J.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4z8b RCSB], [http://www.ebi.ac.uk/pdbsum/4z8b PDBsum]</span></td></tr>

~~Description~~: ~~crystal structure of a DGL mutant~~ -~~H51G H131N~~

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[http://www.uniprot.org/uniprot/LECA_DIOGR LECA_DIOGR]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 50 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bravo, J]]

[[Category: Calevete, J J]]

[[Category: Perez, A]]

[[Category: Sanz, L]]

~~[[Category: Perez, A]]~~

[[Category: Zamora-Caballero, S]]

[[Category: ~~Bravo, J~~]]

[[Category: Dioclea grandiflora]]

[[Category: ~~Calevete, J.J~~]]

[[Category: H31a-h151n mutant]]

[[Category: Lectin]]

[[Category: Sugar binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==crystal structure of a DGL mutant - H51G H131N==
+<StructureSection load='4z8b' size='340' side='right' caption='[[4z8b]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-The entry 4z8b is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4z8b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z8B FirstGlance]. <br>
-Authors: Zamora-Caballero, S., Perez, A., Sanz, L., Bravo, J., Calevete, J.J.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XMM:(2R,3S,4S,5S,6R)-2-(5-BROMO-4-CHLORO-1H-INDOL-3-YLOXY)-TETRAHYDRO-6-(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL'>XMM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4z8b RCSB], [http://www.ebi.ac.uk/pdbsum/4z8b PDBsum]</span></td></tr>
-Description: crystal structure of a DGL mutant -H51G H131N
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/LECA_DIOGR LECA_DIOGR]] D-mannose/D-glucose-binding lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 50 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bravo, J]]
+[[Category: Calevete, J J]]
+[[Category: Perez, A]]
 [[Category: Sanz, L]]
-[[Category: Perez, A]]
 [[Category: Zamora-Caballero, S]]
-[[Category: Bravo, J]]
+[[Category: Dioclea grandiflora]]
-[[Category: Calevete, J.J]]
+[[Category: H31a-h151n mutant]]
+[[Category: Lectin]]
+[[Category: Sugar binding protein]]