High mobility group protein: Difference between revisions

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<StructureSection load='2gzk' size='340' side='right' caption='Rat HMG1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''>
<StructureSection load='2gzk' size='340' side='right' caption='Rat HMGB1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''>
'''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and regulater transcription.  HMG superfamilies differ by their DNA-binding domains.  '''HMGA'''s bind via an AT-hook domain.  '''HMGB'''s bind via box domain.  '''HMGN'''s bind via a nucleosome binding domain.  For details on HMGA see [[HMGI(Y)]].
== Function ==
== Function ==
'''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and regulator transcription.  HMG superfamilies differ by their DNA-binding domains.<br />
* '''HMGA'''s bind via an AT-hook domain.  For details on HMGA see [[HMGI(Y)]].<br />
* '''HMGB'''s bind via box domain<ref>PMID:17979838</ref>.<br />
* '''HMGN'''s bind via a nucleosome binding domain.<br /> 


== Disease ==
== Disease ==
Rearrangements of the HMGA2 gene were detected in human benign lipoma tumors<ref>PMID:11576996</ref>.


== Relevance ==
== Relevance ==
Overexpression of HMGB1 is associated with cancer and is targeted for cancer therapy<ref>PMID:20123075</ref>.


== Structural highlights ==
== Structural highlights ==
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