Sandbox Reserved 1061: Difference between revisions

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The <scene name='69/694228/Nrdh_structure/1'>MtNrdH structure</scene> determined by x-ray crystallography has 79 residues in a single polypeptide chain. The active site (shown in green) is dominated by a <scene name='69/694228/Nrdh_structure/3'>disulfide bond</scene> between Cys-11 and Cys-14, which serves as the site of reduction by thioredoxin reductase. <ref name="Swastik" />
The <scene name='69/694228/Nrdh_structure/1'>MtNrdH structure</scene> determined by x-ray crystallography has 79 residues in a single polypeptide chain. The active site (shown in green) is dominated by a <scene name='69/694228/Nrdh_structure/3'>disulfide bond</scene> between Cys-11 and Cys-14, which serves as the site of reduction by thioredoxin reductase. <ref name="Swastik" />


Many thioredoxin-like proteins have a similar active site region, which includes the <scene name='69/694228/Nrdh_structure/4'>thioredoxin fold</scene>, a large turn in the protein structure right before the disulfide bond. The residues directly following the fold, <scene name='69/694228/Nrdh_structure/5'>CVQC</scene>, are the most highly conserved of all areas of the protein across multiple species.  
Many thioredoxin-like proteins have a similar active site region, which includes the  
<scene name='69/694228/Nrdh_structure/6'>thioredoxin fold</scene>, a large turn in the protein structure right before the disulfide bond. The residues directly following the fold, <scene name='69/694228/Nrdh_structure/5'>CVQC</scene>, are the most highly conserved of all areas of the protein across multiple species.  
[[Image:Weblogocvqc.png|thumb|center|upright=2.5|Weblogo diagram showing highly conserved CVQC region of NrdH in five separate protein structures from ''Nocardiaseriolae'', ''E. coli'', ''Cornebacterium Ammoniagenes'', and ''Mycobacterium Tuberculosis''.<ref name="weblogo">Crooks GE, Hon G, Chandonia JM, Brenner SE WebLogo: A sequence logo generator,
[[Image:Weblogocvqc.png|thumb|center|upright=2.5|Weblogo diagram showing highly conserved CVQC region of NrdH in five separate protein structures from ''Nocardiaseriolae'', ''E. coli'', ''Cornebacterium Ammoniagenes'', and ''Mycobacterium Tuberculosis''.<ref name="weblogo">Crooks GE, Hon G, Chandonia JM, Brenner SE WebLogo: A sequence logo generator,
Genome Research, 14:1188-1190, (2004)</ref>]]
Genome Research, 14:1188-1190, (2004)</ref>]]
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