4ui1: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of the human RGMC-BMP2 complex==

~~The entry~~ 4ui1 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4ui1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI1 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UI1 FirstGlance].

~~Authors~~: ~~Healey, E~~.G., ~~Bishop~~, B., ~~Elegheert~~, J., ~~Bell~~, C.H., ~~Padilla~~-~~Parra~~, S., ~~Siebold, C~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>

~~Description: Crystal structure of the human RGMC-BMP2 complex~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ui1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ui1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ui1 PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

[[~~Category~~: ~~Padilla-Parra, S~~]]

== Disease ==

[[~~Category~~: ~~Healey, E~~.G]]

[[http://www.uniprot.org/uniprot/RGMC_HUMAN RGMC_HUMAN]] Hemochromatosis type 2. The disease is caused by mutations affecting the gene represented in this entry.

[[Category: Bell, C.H]]

== Function ==

[[http://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation. [[http://www.uniprot.org/uniprot/RGMC_HUMAN RGMC_HUMAN]] Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.[UniProtKB:Q7TQ32]

__TOC__

</StructureSection>

[[Category: Bell, C H]]

[[Category: Bishop, B]]

[[Category: Elegheert, J]]

[[Category: Healey, E G]]

[[Category: Padilla-Parra, S]]

[[Category: Siebold, C]]

[[Category: Axon guidance]]

[[Category: Bone morphogenetic protein pathway]]

[[Category: Cell surface receptor signaling]]

[[Category: Hemojuvelin]]

[[Category: Morphogen]]

[[Category: Signaling protein]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of the human RGMC-BMP2 complex==
+<StructureSection load='4ui1' size='340' side='right' caption='[[4ui1]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-The entry 4ui1 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ui1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UI1 FirstGlance]. <br>
-Authors: Healey, E.G., Bishop, B., Elegheert, J., Bell, C.H., Padilla-Parra, S., Siebold, C.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhy|4uhy]], [[4uhz|4uhz]], [[4ui0|4ui0]], [[4ui2|4ui2]]</td></tr>
-Description: Crystal structure of the human RGMC-BMP2 complex
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ui1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ui1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ui1 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Padilla-Parra, S]]
+== Disease ==
-[[Category: Healey, E.G]]
+[[http://www.uniprot.org/uniprot/RGMC_HUMAN RGMC_HUMAN]] Hemochromatosis type 2. The disease is caused by mutations affecting the gene represented in this entry.
-[[Category: Bell, C.H]]
+== Function ==
+[[http://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation. [[http://www.uniprot.org/uniprot/RGMC_HUMAN RGMC_HUMAN]] Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.[UniProtKB:Q7TQ32]
+__TOC__
+</StructureSection>
+[[Category: Bell, C H]]
 [[Category: Bishop, B]]
 [[Category: Elegheert, J]]
+[[Category: Healey, E G]]
+[[Category: Padilla-Parra, S]]
 [[Category: Siebold, C]]
+[[Category: Axon guidance]]
+[[Category: Bone morphogenetic protein pathway]]
+[[Category: Cell surface receptor signaling]]
+[[Category: Hemojuvelin]]
+[[Category: Morphogen]]
+[[Category: Signaling protein]]