4ui2: Difference between revisions
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''' | ==Crystal structure of the ternary RGMB-BMP2-NEO1 complex== | ||
<StructureSection load='4ui2' size='340' side='right' caption='[[4ui2]], [[Resolution|resolution]] 3.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ui2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UI2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhy|4uhy]], [[4uhz|4uhz]], [[4ui0|4ui0]], [[4ui1|4ui1]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ui2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ui2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ui2 PDBsum]</span></td></tr> | |||
[[ | </table> | ||
[[ | == Function == | ||
[[ | [[http://www.uniprot.org/uniprot/RGMB_HUMAN RGMB_HUMAN]] Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. [[http://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE]] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [[http://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation. | ||
[[Category: Bell, C | __TOC__ | ||
</StructureSection> | |||
[[Category: Bell, C H]] | |||
[[Category: Bishop, B]] | [[Category: Bishop, B]] | ||
[[Category: Elegheert, J]] | [[Category: Elegheert, J]] | ||
[[Category: Healey, E G]] | |||
[[Category: Padilla-Parra, S]] | |||
[[Category: Siebold, C]] | [[Category: Siebold, C]] | ||
[[Category: Axon guidance]] | |||
[[Category: Bone morphogenetic protein pathway]] | |||
[[Category: Cell surface receptor signaling]] | |||
[[Category: Hemojuvelin]] | |||
[[Category: Morphogen]] | |||
[[Category: Neogenin]] | |||
[[Category: Repulsive guidance molecule]] | |||
[[Category: Signaling protein]] | |||
Revision as of 12:59, 6 May 2015
Crystal structure of the ternary RGMB-BMP2-NEO1 complex
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