4zbp: Difference between revisions

Revision as of 11:10, 9 September 2015

Crystal structure of the AMPCPR-bound AtNUDT7

Structural highlights

4zbp is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	ADV, SO4
Related:	4zb3
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[NUDT7_ARATH] Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use both NADH and ADP-ribose as substrates, but not 8-oxo-dGTP, cyclic ADP-ribose, GDP-manose, UDP-glucose, ATP, or GTP. Exerts negative control of EDS1 signaling.^[1] ^[2] ^[3] ^[4] ^[5]

References

↑ Ogawa T, Ueda Y, Yoshimura K, Shigeoka S. Comprehensive analysis of cytosolic Nudix hydrolases in Arabidopsis thaliana. J Biol Chem. 2005 Jul 1;280(26):25277-83. Epub 2005 May 5. PMID:15878881 doi:https://dx.doi.org/M503536200
↑ Olejnik K, Kraszewska E. Cloning and characterization of an Arabidopsis thaliana Nudix hydrolase homologous to the mammalian GFG protein. Biochim Biophys Acta. 2005 Sep 25;1752(2):133-41. PMID:16154395 doi:https://dx.doi.org/10.1016/j.bbapap.2005.07.021
↑ Jambunathan N, Mahalingam R. Analysis of Arabidopsis growth factor gene 1 (GFG1) encoding a nudix hydrolase during oxidative signaling. Planta. 2006 Jun;224(1):1-11. Epub 2005 Dec 3. PMID:16328543 doi:https://dx.doi.org/10.1007/s00425-005-0183-y
↑ Bartsch M, Gobbato E, Bednarek P, Debey S, Schultze JL, Bautor J, Parker JE. Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7. Plant Cell. 2006 Apr;18(4):1038-51. Epub 2006 Mar 10. PMID:16531493 doi:https://dx.doi.org/tpc.105.039982
↑ Ge X, Li GJ, Wang SB, Zhu H, Zhu T, Wang X, Xia Y. AtNUDT7, a negative regulator of basal immunity in Arabidopsis, modulates two distinct defense response pathways and is involved in maintaining redox homeostasis. Plant Physiol. 2007 Sep;145(1):204-15. Epub 2007 Jul 27. PMID:17660350 doi:https://dx.doi.org/pp.107.103374

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Ogawa T, Ueda Y, Yoshimura K, Shigeoka S. Comprehensive analysis of cytosolic Nudix hydrolases in Arabidopsis thaliana. J Biol Chem. 2005 Jul 1;280(26):25277-83. Epub 2005 May 5. PMID:15878881 doi:https://dx.doi.org/M503536200

[2] Olejnik K, Kraszewska E. Cloning and characterization of an Arabidopsis thaliana Nudix hydrolase homologous to the mammalian GFG protein. Biochim Biophys Acta. 2005 Sep 25;1752(2):133-41. PMID:16154395 doi:https://dx.doi.org/10.1016/j.bbapap.2005.07.021

[3] Jambunathan N, Mahalingam R. Analysis of Arabidopsis growth factor gene 1 (GFG1) encoding a nudix hydrolase during oxidative signaling. Planta. 2006 Jun;224(1):1-11. Epub 2005 Dec 3. PMID:16328543 doi:https://dx.doi.org/10.1007/s00425-005-0183-y

[4] Bartsch M, Gobbato E, Bednarek P, Debey S, Schultze JL, Bautor J, Parker JE. Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7. Plant Cell. 2006 Apr;18(4):1038-51. Epub 2006 Mar 10. PMID:16531493 doi:https://dx.doi.org/tpc.105.039982

[5] Ge X, Li GJ, Wang SB, Zhu H, Zhu T, Wang X, Xia Y. AtNUDT7, a negative regulator of basal immunity in Arabidopsis, modulates two distinct defense response pathways and is involved in maintaining redox homeostasis. Plant Physiol. 2007 Sep;145(1):204-15. Epub 2007 Jul 27. PMID:17660350 doi:https://dx.doi.org/pp.107.103374

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of the AMPCPR-bound AtNUDT7==
+<StructureSection load='4zbp' size='340' side='right' caption='[[4zbp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-The entry 4zbp is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4zbp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZBP FirstGlance]. <br>
-Authors: Tang, Q., Liu, C., Zhong, C., Ding, J.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADV:ALPHA-BETA+METHYLENE+ADP-RIBOSE'>ADV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zb3|4zb3]]</td></tr>
-Description: Crystal structure of plant protein
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zbp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zbp RCSB], [http://www.ebi.ac.uk/pdbsum/4zbp PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NUDT7_ARATH NUDT7_ARATH]] Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use both NADH and ADP-ribose as substrates, but not 8-oxo-dGTP, cyclic ADP-ribose, GDP-manose, UDP-glucose, ATP, or GTP. Exerts negative control of EDS1 signaling.<ref>PMID:15878881</ref> <ref>PMID:16154395</ref> <ref>PMID:16328543</ref> <ref>PMID:16531493</ref> <ref>PMID:17660350</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ding, J]]
+[[Category: Liu, C]]
 [[Category: Tang, Q]]
 [[Category: Zhong, C]]
-[[Category: Liu, C]]
+[[Category: Ampcpr]]
-[[Category: Ding, J]]
+[[Category: Closed conformation]]
+[[Category: Hydrolase]]
+[[Category: Nudix]]

4zbp: Difference between revisions

Revision as of 11:10, 9 September 2015

Crystal structure of the AMPCPR-bound AtNUDT7

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools