Sandbox Reserved 1084: Difference between revisions

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HDAC8 has a some structural features which make it different from other HDACs. It lacks the C-terminal sequence the others use to recruit cofactors <ref name="somoza">Somoza, J. R. et al. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. Structure 12, 1325–1334 (2004).</ref>. The studies of HDAC8 with different hydroxamate inhibitors: <scene name='69/699997/Hdac8_tsa_bound/4'>TSA</scene>, <scene name='69/699997/Hdac8_binding_saha/6'>SAHA</scene> and <scene name='69/699997/Hdac8_binding_m-334/3'>M-334</scene> shows that there is a certain amount of flexibility in its active site pocket. This seems to be due to the presence of the <scene name='69/699997/L1_loop/4'>L1 loop (S30-K38)</scene> <ref name="somoza" />.

Sandbox Reserved 1084: Difference between revisions

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Revision as of 17:53, 23 April 2015 view source Student (talk \| contribs) students 33,923 edits No edit summary ← Older edit		Revision as of 17:53, 23 April 2015 view source Student (talk \| contribs) students 33,923 edits No edit summary Newer edit →
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	HDAC8 has a some structural features which make it different from other HDACs. It lacks the C-terminal sequence the others use to recruit cofactors <ref name="somoza">Somoza, J. R. et al. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. Structure 12, 1325–1334 (2004).</ref>. The studies of HDAC8 with different hydroxamate inhibitors: <scene name='69/699997/Hdac8_tsa_bound/4'>TSA</scene>, <scene name='69/699997/Hdac8_binding_saha/6'>SAHA</scene> and <scene name='69/699997/Hdac8_binding_m-334/3'>M-334</scene> shows that there is a certain amount of flexibility in its active site pocket. This seems to be due to the presence of the <scene name='69/699997/L1_loop/4'>L1 loop (S30-K38)</scene> <ref name="somoza" />.		HDAC8 has a some structural features which make it different from other HDACs. It lacks the C-terminal sequence the others use to recruit cofactors <ref name="somoza">Somoza, J. R. et al. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. Structure 12, 1325–1334 (2004).</ref>. The studies of HDAC8 with different hydroxamate inhibitors: <scene name='69/699997/Hdac8_tsa_bound/4'>TSA</scene>, <scene name='69/699997/Hdac8_binding_saha/6'>SAHA</scene> and <scene name='69/699997/Hdac8_binding_m-334/3'>M-334</scene> shows that there is a certain amount of flexibility in its active site pocket. This seems to be due to the presence of the <scene name='69/699997/L1_loop/4'>L1 loop (S30-K38)</scene> <ref name="somoza" />.