Sandbox Reserved 1088: Difference between revisions

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== Conclusion ==
== Conclusion ==


The inter-domain interface is essential in providing protein flexibility and hence modulating viral replication. The cross-talk between the MTase and RdRp domains is enhanced by the presence of a unique and electrostatic-rich interface specific to DENV.  
The inter-domain interface is characterized by a unique and electrostatic-rich network specific to DENV which enhances communication between and hence the function of the MTase and RdRp domains. Which, together with the linker region are essential in providing protein flexibility and therefore modulating viral replication and ultimately infectivity.




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