Sandbox Reserved 1061: Difference between revisions
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==Possible Drug Target== | ==Possible Drug Target== | ||
MtNrdH can serve as a potential drug target to treat tuberculosis. The genes encoding NrdE and NrdF2, a cofactor in class 1b ribonucleotide reduction, are essential for growth of M. tuberculosis in vitro.<ref>Mowa, M. B., et al. (2009) Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria. J. Bacteriol. 191 (3), 985−995</ref> This | MtNrdH can serve as a potential drug target to treat tuberculosis. The genes encoding NrdE and NrdF2, a cofactor in class 1b ribonucleotide reduction, are essential for growth of M. tuberculosis in vitro.<ref>Mowa, M. B., et al. (2009) Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria. J. Bacteriol. 191 (3), 985−995</ref> This suggests that M. tuberculosis relies solely on class Ib ribonucleotide reduction. If that is the case, NrdH may be an essential gene as well. Since NrdH is not found in humans, a drug that targets NrdH would be able to damage M. tuberculosis cells without hurting the human host. | ||
</StructureSection> | </StructureSection> | ||
