Sandbox WWC4: Difference between revisions

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''''''''Aquaporin (AQP)'''''''' The water channel of the cell

This is a membrane proteins that control the amount of water that travels in and out of the cell. Before the discovery of aquaporin, it was thought that water molecule just leaked through the phospholipid bilayer.

This is a integral membrane proteins that control the amount of water that travels in and out of the cell. Before the discovery of aquaporin, it was thought that water molecule just leaked through the phospholipid bilayer.

Aquaporins allow water to flow rapidly to the inside of cell then it would by crossing the bilayer.

This protein is highly selective to water molecules , preventing the passage of ions and other solutes.There are multiple types of aquaporins that can allow the transport of other molecules such as glycerol,CO2, ammonia and urea by aquaglyceroporin. It depends on the size of the pore; aquaporin 3 channel has a pore width of 8-10 Ångströms and allows the passage of hydrophilic molecules ranging between 150-200 Da. Aquaporins water channel are impermeable to protons and other charged species

Water molecules traverse through the pore of the channel in single file. The presence of water channels increases membrane permeability to water.

~~----~~

'''Structure'''

~~[[Structure]]~~

Aquaporin is protien with six transmembrane alpha helices with the amino and craboxyl terminal located in the cytoplasm.

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Function

The location of Aquaporin is usually found in the kidney, eye and plants.

There are thirteen known types of aquaporins in mammals, and six of these are located in the kidney. The most studied aquaporins are AQP1, AQP2, AQP3, and AQP4.The location of Aquaporin is usually found in the kidney, eye and plants. It is found in the basolateral and apical plasma membranes of the proximal tubules and the limb of the loop of Henle in the kidney.

Aquaporin are concentrated in the kidney is h

Aquaporin are concentrated in the kidney is where there is a need to transporting large amounts of water in and out of the cell.

If a person is identified with severe or total deficiency in aquaporin-1. They are generally healthy, they might have a disorder that cause an increase in urine production.

Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, and lungs.

~~integral membrane proteins from a larger family of major intrinsic proteins (MIP)~~

~~A small number of people have been identified with severe or total deficiency in aquaporin-1. Interestingly, they are generally healthy~~

defect in the ability to concentrate solutes in the urine and to conserve water when deprived of drinking water play a key role in acquired forms of nephrogenic diabetes insipidus (disorders that cause increased urine production

~~There are thirteen known types of aquaporins in mammals, and six of these are located in the kidney. The most studied aquaporins are AQP1, AQP2, AQP3, and AQP4.~~

~~. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, and lungs.~~

~~t is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle,~~

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@@ Line 4: / Line 4: @@
 ''''''''Aquaporin (AQP)'''''''' The water channel of the cell
-This is a membrane proteins that control the amount of water that travels in and out of the cell. Before the discovery of aquaporin, it was thought that water molecule just leaked through the phospholipid bilayer.
+This is a integral membrane proteins that control the amount of water that travels in and out of the cell. Before the discovery of aquaporin, it was thought that water molecule just leaked through the phospholipid bilayer.
 Aquaporins allow water to flow rapidly to the inside of cell then it would by crossing the bilayer.
 This protein is highly selective to water molecules , preventing the passage of ions and other solutes.There are multiple types of aquaporins that can allow the transport of other molecules such as glycerol,CO2, ammonia and urea  by aquaglyceroporin. It depends on the size of the pore; aquaporin 3 channel has a pore width of 8-10 Ångströms and allows the passage of hydrophilic molecules ranging between 150-200 Da. Aquaporins water channel are impermeable to protons and other charged species
 Water molecules traverse through the pore of the channel in single file. The presence of water channels increases membrane permeability to water.
-----
+'''Structure'''
-[[Structure]]
 Aquaporin is  protien with six transmembrane alpha helices with the amino and craboxyl terminal located in the cytoplasm.
@@ Line 34: / Line 33: @@
 Function
-The location of Aquaporin is usually found in the kidney, eye and plants.
+There are thirteen known types of aquaporins in mammals, and six of these are located in the kidney. The most studied aquaporins are AQP1, AQP2, AQP3, and AQP4.The location of Aquaporin is usually found in the kidney, eye and plants. It is found in the basolateral and apical plasma membranes of the proximal tubules and the limb of the loop of Henle in the kidney.
-Aquaporin are concentrated in the kidney is h
+Aquaporin are concentrated in the kidney is where there is a need to transporting large amounts of water in and out of the cell.
+If a person is identified with severe or total deficiency in aquaporin-1. They are generally healthy, they might have a disorder that cause an increase in urine production.
+Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, and lungs.
-integral membrane proteins from a larger family of major intrinsic proteins (MIP)
-A small number of people have been identified with severe or total deficiency in aquaporin-1. Interestingly, they are generally healthy
- defect in the ability to concentrate solutes in the urine and to conserve water when deprived of drinking water play a key role in acquired forms of nephrogenic diabetes insipidus (disorders that cause increased urine production
-There are thirteen known types of aquaporins in mammals, and six of these are located in the kidney. The most studied aquaporins are AQP1, AQP2, AQP3, and AQP4.
-. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, and lungs.
-t is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle,
 ----