4zej: Difference between revisions
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''' | ==Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime== | ||
<StructureSection load='4zej' size='340' side='right' caption='[[4zej]], [[Resolution|resolution]] 1.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4zej]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEJ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wd6|4wd6]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zej OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zej RCSB], [http://www.ebi.ac.uk/pdbsum/4zej PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A carbapenem-resistant Pseudomonas stutzeri strain isolated from a Dutch patient was analyzed in detail. This isolate produced a metallo-beta-lactamase (MBL) whose gene, with 43.5% GC content, was cloned and expressed in Escherichia coli. beta-Lactamase DIM-1 (for Dutch imipenemase) was weakly related to other Ambler class B beta-lactamases, sharing <52% amino acid identity with the most closely related MBL, GIM-1, and 45% identity with IMP-type MBLs. The beta-Lactamase DIM-1 significantly hydrolyzed broad-spectrum cephalosporins and carbapenems and spared aztreonam. This MBL gene was embedded in a class 1 integron containing two other gene cassettes, encoding resistance to aminoglycosides and disinfectants, that was located on a 70-kb plasmid. | |||
Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands.,Poirel L, Rodriguez-Martinez JM, Al Naiemi N, Debets-Ossenkopp YJ, Nordmann P Antimicrob Agents Chemother. 2010 Jun;54(6):2420-4. doi: 10.1128/AAC.01456-09., Epub 2010 Mar 22. PMID:20308383<ref>PMID:20308383</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Booth, M P.S]] | |||
[[Category: Kosmopoulou, M]] | |||
[[Category: Spencer, J]] | [[Category: Spencer, J]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Zinc metalloenzyme]] | ||
Revision as of 15:53, 27 May 2015
Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime
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