Menin: Difference between revisions
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<StructureSection load=' | <StructureSection load='3u86' size='340' side='right' caption='Structure of human menin complex with piperidine derivative inhibitor, tetraethylene glycol, DMSO and sulfate (PDB code [[4og6]]).' scene=''> | ||
== Function == | == Function == | ||
'''Menin''' (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD. | '''Menin''' (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD<ref>PMID:11524225</ref>. | ||
== Disease == | == Disease == | ||
Men mutations may be a common mechanism for inactivating tumor suppressor gene products in familial cancer<ref>PMID:15254225</ref>. | |||
== Relevance == | == Relevance == | ||
Revision as of 08:52, 20 April 2016
<StructureSection load='3u86' size='340' side='right' caption='Structure of human menin complex with piperidine derivative inhibitor, tetraethylene glycol, DMSO and sulfate (PDB code 4og6).' scene=>
Function
Menin (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD[1].
Disease
Men mutations may be a common mechanism for inactivating tumor suppressor gene products in familial cancer[2].
Relevance
Structural highlights
3D structures of menin
Updated on 20-April-2016
3u84 – hMen – human
4og3, 4og4, 4og5, 4og6, 4og7, 4og8 – hMen + inhibitor
4gpq, 4gq3, 4gq4, 4x5y, 4x5z – hMen (mutant) + inhibitor
4i80 – hMen + peptide inhibitor
3u85 – hMen + histone-lysine N-methyltransferase Mll peptide
4gq6 – hMen (mutant) + histone-lysine N-methyltransferase Mll peptide
3u86 – hMen + JunD peptide
3u88 – hMen + histone-lysine N-methyltransferase Mll + lens epithelium-derived growth factor
References
- ↑ Baillard C, Hellier P, Barillot C. Segmentation of brain 3D MR images using level sets and dense registration. Med Image Anal. 2001 Sep;5(3):185-94. PMID:11524225
- ↑ Yaguchi H, Ohkura N, Takahashi M, Nagamura Y, Kitabayashi I, Tsukada T. Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway. Mol Cell Biol. 2004 Aug;24(15):6569-80. PMID:15254225 doi:https://dx.doi.org/10.1128/MCB.24.15.6569-6580.2004
