4qpf: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''
==New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption==
 
<StructureSection load='4qpf' size='340' side='right' caption='[[4qpf]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
The entry 4qpf is ON HOLD  until Jun 24 2016
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4qpf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QPF FirstGlance]. <br>
Authors: Ebetino, F.H., Lundy, M., Kwaasi, A.A., Dunford, J.E., Duan, Z., Triffitt, J., Mazur, A., Jeans, G., Barnett, B.L., Russell, R.G.G.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=39L:[1-FLUORO-2-(IMIDAZO[1,2-A]PYRIDIN-3-YL)ETHANE-1,1-DIYL]BIS(PHOSPHONIC+ACID)'>39L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zw5|1zw5]], [[1yq7|1yq7]], [[2vf6|2vf6]], [[3b7l|3b7l]]</td></tr>
Description: New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qpf RCSB], [http://www.ebi.ac.uk/pdbsum/4qpf PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.  
__TOC__
</StructureSection>
[[Category: Barnett, B L]]
[[Category: Duan, Z]]
[[Category: Dunford, J E]]
[[Category: Ebetino, F H]]
[[Category: Jeans, G]]
[[Category: Jeans, G]]
[[Category: Barnett, B.L]]
[[Category: Kwaasi, A A]]
[[Category: Duan, Z]]
[[Category: Russell, R.G.G]]
[[Category: Dunford, J.E]]
[[Category: Lundy, M]]
[[Category: Lundy, M]]
[[Category: Mazur, A]]
[[Category: Mazur, A]]
[[Category: Russell, R G.G]]
[[Category: Triffitt, J]]
[[Category: Triffitt, J]]
[[Category: Kwaasi, A.A]]
[[Category: All-alpha helical prenyltransferase]]
[[Category: Ebetino, F.H]]
[[Category: Bisphosphonate]]
[[Category: Cholesterol synthesis]]
[[Category: Dimethylallyl pyrophosphate]]
[[Category: Isopentyl pyrophosphate]]
[[Category: Isoprene biosynthesis]]
[[Category: Isoprenoid pathway]]
[[Category: Lipid synthesis]]
[[Category: Steroid biosynthesis]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4qpf"