4w63: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A TACRINE-BENZOFURAN HYBRID INHIBITOR==

~~The entry~~ 4w63 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4w63]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W63 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W63 FirstGlance].

~~Authors~~: ~~Pesaresi~~, A., ~~Samez~~, S., ~~Lamba, D~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=HTB:N-(1-BENZOFURAN-2-YLMETHYL)-N-(1,2,3,4-TETRAHYDROACRIDIN-9-YL)HEPTANE-1,7-DIAMINE'>HTB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </td></tr>

~~Description~~: ~~TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A TACRINE~~-~~BENZOFURAN HYBRID INHIBITOR~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w63 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w63 RCSB], [http://www.ebi.ac.uk/pdbsum/4w63 PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

[[Category: ~~Samez, S~~]]

== Function ==

[[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.

__TOC__

</StructureSection>

[[Category: Acetylcholinesterase]]

[[Category: Torpedo californica]]

[[Category: Lamba, D]]

[[Category: Pesaresi, A]]

[[Category: Samez, S]]

[[Category: Benzofuran]]

[[Category: Enzyme-inhibitor complex]]

[[Category: Hydrolase]]

[[Category: Multitarget drug]]

[[Category: Tacrine]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A TACRINE-BENZOFURAN HYBRID INHIBITOR==
+<StructureSection load='4w63' size='340' side='right' caption='[[4w63]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-The entry 4w63 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4w63]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W63 FirstGlance]. <br>
-Authors: Pesaresi, A., Samez, S., Lamba, D.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTB:N-(1-BENZOFURAN-2-YLMETHYL)-N-(1,2,3,4-TETRAHYDROACRIDIN-9-YL)HEPTANE-1,7-DIAMINE'>HTB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-Description: TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A TACRINE-BENZOFURAN HYBRID INHIBITOR
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w63 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w63 RCSB], [http://www.ebi.ac.uk/pdbsum/4w63 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Samez, S]]
+== Function ==
+[[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
+__TOC__
+</StructureSection>
+[[Category: Acetylcholinesterase]]
+[[Category: Torpedo californica]]
 [[Category: Lamba, D]]
 [[Category: Pesaresi, A]]
+[[Category: Samez, S]]
+[[Category: Benzofuran]]
+[[Category: Enzyme-inhibitor complex]]
+[[Category: Hydrolase]]
+[[Category: Multitarget drug]]
+[[Category: Tacrine]]