User:Wayne Decatur/Gal 4: Difference between revisions

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Gal4p is a transcriptional activator in'''Saccharomyces cerevisiae''' that regulates the expression of genes to coordinate the response to the carbon source galactose.
Gal4p is a transcriptional activator in'''Saccharomyces cerevisiae''' that regulates the expression of genes to coordinate the response to the carbon source galactose. Structures




<Structure load='Insert PDB code or filename here' size='550' frame='true' align='right' caption='The N-terminal amino acids of Gal4p bound to DNA.' scene='70/701975/1d66_firstglance/1' />
<Structure load='Insert PDB code or filename here' size='550' frame='true' align='right' caption='The N-terminal amino acids of Gal4p bound to DNA.' scene='70/701975/1d66_firstglance/1' />


===DNA Recognition by Gal4p===
Gal4p is a transcriptional activator in'''Saccharomyces cerevisiae''' that regulates genes in response to the carbon source galactose.
Gal4p is a transcriptional activator in'''Saccharomyces cerevisiae''' that regulates genes in response to the carbon source galactose.
The protein binds as a dimer to a symmetrical 17-base-pair sequence
The structure of The protein binds as a dimer to a symmetrical 17-base-pair sequence. Specifically, the consensus Gal4-binding site is a 17-mer of sequence 5′-CGG-N11-CCG-3′.


==Reference==
==Reference==
<ref group="xtra">PMID:1557122</ref><references group="xtra"/>
<ref group="xtra">PMID:1557122</ref><references group="xtra"/>

Revision as of 15:33, 12 May 2015

Gal4p is a transcriptional activator inSaccharomyces cerevisiae that regulates the expression of genes to coordinate the response to the carbon source galactose. Structures


The N-terminal amino acids of Gal4p bound to DNA.

Drag the structure with the mouse to rotate

DNA Recognition by Gal4p

Gal4p is a transcriptional activator inSaccharomyces cerevisiae that regulates genes in response to the carbon source galactose. The structure of The protein binds as a dimer to a symmetrical 17-base-pair sequence. Specifically, the consensus Gal4-binding site is a 17-mer of sequence 5′-CGG-N11-CCG-3′.

Reference

  1. Marmorstein R, Carey M, Ptashne M, Harrison SC. DNA recognition by GAL4: structure of a protein-DNA complex. Nature. 1992 Apr 2;356(6368):408-14. PMID:1557122 doi:https://dx.doi.org/10.1038/356408a0

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Wayne Decatur

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