4yfz: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structural basis of glycan recognition in neonate-specific rotaviruses==

~~The entry~~ 4yfz is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4yfz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YFZ OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YFZ FirstGlance].

~~Authors~~: Hu, L., ~~Prasad~~, B.V.V.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

~~Description~~: ~~Structural basis~~ of ~~glycan recognition in neonate~~-~~specific rotaviruses~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yfz OCA], [http://pdbe.org/4yfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yfz RCSB], [http://www.ebi.ac.uk/pdbsum/4yfz PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures]~~]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/B6RGK2_9REOV B6RGK2_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment (By similarity).[SAAS:SAAS00209906] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (By similarity).[SAAS:SAAS00209911]

__TOC__

</StructureSection>

[[Category: Hu, L]]

[[Category: Prasad, B.V.V]]

[[Category: Prasad, B V.V]]

[[Category: Glycan]]

[[Category: Rotavirus]]

[[Category: Structural biology]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structural basis of glycan recognition in neonate-specific rotaviruses==
+<StructureSection load='4yfz' size='340' side='right' caption='[[4yfz]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-The entry 4yfz is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4yfz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YFZ FirstGlance]. <br>
-Authors: Hu, L., Prasad, B.V.V.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yfw|4yfw]], [[4ye2|4ye2]], [[4yg0|4yg0]], [[4yg3|4yg3]], [[4yg6|4yg6]]</td></tr>
-Description: Structural basis of glycan recognition in neonate-specific rotaviruses
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yfz OCA], [http://pdbe.org/4yfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yfz RCSB], [http://www.ebi.ac.uk/pdbsum/4yfz PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/B6RGK2_9REOV B6RGK2_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment (By similarity).[SAAS:SAAS00209906]  VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (By similarity).[SAAS:SAAS00209911]
+__TOC__
+</StructureSection>
 [[Category: Hu, L]]
-[[Category: Prasad, B.V.V]]
+[[Category: Prasad, B V.V]]
+[[Category: Glycan]]
+[[Category: Rotavirus]]
+[[Category: Structural biology]]
+[[Category: Viral protein]]