4zm0: Difference between revisions
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==Antitoxin Phd from phage P1 in complex with its operator DNA inverted repeat== | |||
<StructureSection load='4zm0' size='340' side='right' caption='[[4zm0]], [[Resolution|resolution]] 3.17Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4zm0]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZM0 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zlx|4zlx]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zm0 OCA], [http://pdbe.org/4zm0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zm0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zm0 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PHD_BPP1 PHD_BPP1]] Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that binds to the doc toxin and neutralizes its toxic effect. Bacteriophage P1 lysogenizes bacteria as a low-copy number plasmid. Phd and doc proteins function in unison to stabilize plasmid number by inducing a lethal response to P1 plasmid prophage loss.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref> Binds to its own promoter repressing its expression; toxin doc acts as a corepressor or derepressor depending on the ratio, repressing or inducing expression.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Garcia-Pino, A]] | [[Category: Garcia-Pino, A]] | ||
[[Category: Loris, R]] | [[Category: Loris, R]] | ||
[[Category: Conditional cooperativity]] | |||
[[Category: Dna binding]] | |||
[[Category: Intrinsic disorder]] | |||
[[Category: Protein-dna complex]] | |||
[[Category: Toxin-antitoxin]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription factor]] | |||
