2z6h: Difference between revisions
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00020 ARM], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00185 ARM]</span> | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6h OCA], [http://www.ebi.ac.uk/pdbsum/2z6h PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2z6h RCSB]</span> | |||
}} | }} | ||
'''Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain''' | '''Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain''' | ||
==Overview== | |||
beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner. | |||
==About this Structure== | ==About this Structure== | ||
2Z6H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6H OCA]. | 2Z6H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6H OCA]. | ||
==Reference== | |||
Crystal Structure of a Full-Length beta-Catenin., Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W, Structure. 2008 Mar;16(3):478-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18334222 18334222] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Liu, J.]] | [[Category: Liu, J.]] | ||
[[Category: Moon, R.]] | [[Category: Moon, R.]] | ||
[[Category: Takemaru, K | [[Category: Takemaru, K.]] | ||
[[Category: Xing, Y.]] | [[Category: Xing, Y.]] | ||
[[Category: Xu, W.]] | [[Category: Xu, W.]] | ||
| Line 40: | Line 48: | ||
[[Category: wnt signaling pathway]] | [[Category: wnt signaling pathway]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 10:03:19 2008'' | ||
Revision as of 08:03, 26 March 2008
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| 2z6h, resolution 2.20Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Domains: | ARM, ARM | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain
Overview
beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner.
About this Structure
2Z6H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal Structure of a Full-Length beta-Catenin., Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W, Structure. 2008 Mar;16(3):478-87. PMID:18334222
Page seeded by OCA on Wed Mar 26 10:03:19 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Homo sapiens
- Single protein
- Liu, J.
- Moon, R.
- Takemaru, K.
- Xing, Y.
- Xu, W.
- Zheng, J.
- Activator
- Alternative splicing
- Beta-catenin
- C-terminal domain
- Cell adhesion
- Crystal structure
- Cytoplasm
- Cytoskeleton
- Disease mutation
- Nucleus
- Phosphorylation
- Polymorphism
- Structural protein
- Transcription
- Transcription regulation
- Ubl conjugation
- Wnt signaling pathway
