2z9g: Difference between revisions
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|PDB= 2z9g |SIZE=350|CAPTION= <scene name='initialview01'>2z9g</scene>, resolution 1.86Å | |PDB= 2z9g |SIZE=350|CAPTION= <scene name='initialview01'>2z9g</scene>, resolution 1.86Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=BNZ:BENZENE'>BNZ</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2z9j|2Z9J]], [[2z9k|2Z9K]], [[2z9l|2Z9L]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9g OCA], [http://www.ebi.ac.uk/pdbsum/2z9g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z9g RCSB]</span> | |||
}} | }} | ||
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[[Category: Lee, C C.]] | [[Category: Lee, C C.]] | ||
[[Category: Wang, A H.]] | [[Category: Wang, A H.]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
[[Category: complex]] | [[Category: complex]] | ||
| Line 49: | Line 50: | ||
[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:19:36 2008'' | ||
Revision as of 02:19, 31 March 2008
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| 2z9g, resolution 1.86Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | BNZ, HG | ||||||||||||
| Related: | 2Z9J, 2Z9K, 2Z9L
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Complex structure of SARS-CoV 3C-like protease with PMA
Overview
Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization.
About this Structure
2Z9G is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.
Reference
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:17981158
Page seeded by OCA on Mon Mar 31 05:19:36 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Sars coronavirus
- Single protein
- Lee, C C.
- Wang, A H.
- Atp-binding
- Complex
- Cytoplasm
- Endonuclease
- Exonuclease
- Helicase
- Hydrolase
- Membrane
- Metal-binding
- Nuclease
- Nucleotide-binding
- Nucleotidyltransferase
- Protease
- Ribosomal frameshift
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Thiol protease
- Transferase
- Transmembrane
- Zinc
- Zinc-finger
