Pre-mRNA-splicing factor: Difference between revisions
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{{STRUCTURE_3e9l| PDB=3e9l | SIZE=400| SCENE= |right|CAPTION=Human pre-mRNA-splicing factor 8 endonuclease domain complex with Na+ (purple) and Cl- (green) ions, [[3e9l]] }} | {{STRUCTURE_3e9l| PDB=3e9l | SIZE=400| SCENE= |right|CAPTION=Human pre-mRNA-splicing factor 8 endonuclease domain complex with Na+ (purple) and Cl- (green) ions, [[3e9l]] }} | ||
== Function == | |||
'''Pre-mRNA-splicing factors (Prp)''' are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing<ref>PMID:10394358</ref>. | |||
''' | *'''Prp3b''' is part of the U2 small nuclear ribonucleoproteins complex (U2 snRNP)<br /> | ||
* | *'''Prp8''' functions as a scaffold which mediates the ordered assembly of spliceosomal proteins and snRNAs. For details see [[Prp8]]<br /> | ||
*[[Prp24]]<br /> | *'''Prp18''' and '''Bud31''' are essential for the catalytic step in pre-mRNA splicing process.<br /> | ||
*'''snRNA-associated-splicing factor 24''' binds preferentially to the U4/U6 hybrid snRNAs. For details see [[Prp24]]<br /> | |||
*[[Prp19]]<br /> | *[[Prp19]]<br /> | ||
*[[Prp40]]. | *[[Prp40]].<br /> | ||
*'''Prpcwc2''' is a yeast splicing factor which plays a role in the generation of a functional splicing center '''Prp RBM22''' is the human homolog of Prpcwc2.<br /> | |||
*'''Prpcwc26''' or '''Bud13''' belongs to the pre-mRNA retention and splicing complex RES.<br /> | |||
== 3D Structures of pre-mRNA splicing factors == | == 3D Structures of pre-mRNA splicing factors == | ||
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*Pre-mRNA-splicing factor 2 | *Pre-mRNA-splicing factor 2 | ||
**[[3beg]] – hPrp | **[[3beg]] – hPrp P33 subunit + Ser/Thr-protein kinase – human<BR /> | ||
**[[2o3d]] – hPrp P33 subunit | **[[2o3d]] – hPrp P33 subunit | ||
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}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
