Prion: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 4: | Line 4: | ||
'''Prion''' (PrP) is a protein which becomes infectious upon undergoing conformation change to an amyloid form, which is self-propagating and becomes resistant to protease degradation. The fungus ''Podospora anserine'' has a prion-like protein HET-S which undergoes a conformation change to amyloid form which prevents its colony from merging with non-compatible colonies. Yeast prion proteins are Sup35 and Ure2. The images at the left and at the right correspond to one representative prion, ''i.e.'' the crystal structure of human prion ([[3haf]]). For more details see<br /> | '''Prion''' (PrP) is a protein which becomes infectious upon undergoing conformation change to an amyloid form, which is self-propagating and becomes resistant to protease degradation. The fungus ''Podospora anserine'' has a prion-like protein HET-S which undergoes a conformation change to amyloid form which prevents its colony from merging with non-compatible colonies. Yeast prion proteins are Sup35 and Ure2. The images at the left and at the right correspond to one representative prion, ''i.e.'' the crystal structure of human prion ([[3haf]]). For more details see<br /> | ||
*[[Prion protein]]<br /> | *[[Prion protein]]<br /> | ||
*[[Human Prion Protein Dimer]] | *[[Human Prion Protein Dimer]]<br /> | ||
*[[Doppel]],<br /> | |||
Click here to see <scene name='Prion/Cv/2'>example of prion unfolding</scene> (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]). | Click here to see <scene name='Prion/Cv/2'>example of prion unfolding</scene> (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]). | ||
