4zqp: Difference between revisions

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'''Unreleased structure'''
==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor MAD1==
 
<StructureSection load='4zqp' size='340' side='right' caption='[[4zqp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
The entry 4zqp is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4zqp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZQP FirstGlance]. <br>
Authors: Kim, Y., Makowska-Grzyska, M., Gu, M., Kavitha, M., Hedstrom, L., Andesrson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=KP3:5-O-({1-[(2E)-4-(4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-1,3-DIHYDRO-2-BENZOFURAN-5-YL)-2-METHYLBUT-2-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)ADENOSINE'>KP3</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zqm|4zqm]], [[4zqn|4zqn]], [[4zqo|4zqo]]</td></tr>
Description: Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor MAD1
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zqp RCSB], [http://www.ebi.ac.uk/pdbsum/4zqp PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Andesrson, W.F]]
== Function ==
[[http://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
__TOC__
</StructureSection>
[[Category: Andesrson, W F]]
[[Category: Structural genomic]]
[[Category: Gu, M]]
[[Category: Hedstrom, L]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak, A]]
[[Category: Makowska-Grzyska, M]]
[[Category: Kavitha, M]]
[[Category: Kavitha, M]]
[[Category: Hedstrom, L]]
[[Category: Gu, M]]
[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
[[Category: Kim, Y]]
[[Category: Kim, Y]]
[[Category: Makowska-Grzyska, M]]
[[Category: Center for membrane proteins of infectious disease]]
[[Category: Delta cb]]
[[Category: Impdh]]
[[Category: Mad1]]
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