4zrp: Difference between revisions
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==TC:CD320== | |||
<StructureSection load='4zrp' size='340' side='right' caption='[[4zrp]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4zrp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRP FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CNC:CO-CYANOCOBALAMIN'>CNC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zrp OCA], [http://pdbe.org/4zrp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zrp RCSB], [http://www.ebi.ac.uk/pdbsum/4zrp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zrp ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[http://omim.org/entry/275350 275350]]. This results in various forms of anemia. [[http://www.uniprot.org/uniprot/CD320_HUMAN CD320_HUMAN]] Methylmalonic aciduria due to transcobalamin receptor defect. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. [[http://www.uniprot.org/uniprot/CD320_HUMAN CD320_HUMAN]] Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.<ref>PMID:11418631</ref> <ref>PMID:18779389</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Alam, A]] | [[Category: Alam, A]] | ||
[[Category: Locher, K | [[Category: Locher, K P]] | ||
[[Category: Ldlr-a]] | |||
[[Category: Transport protein]] | |||
[[Category: Vitamin transporter]] | |||
