Protein phosphatase

Protein phosphatases (PP) regular protein phosphorylation and thus are key in intracellular signal transduction processes.

• PP1 is a serine/threonine phosphatase.
  
• PP2A targets proteins in the oncogenic signaling pathways. For PP2A see also HEAT Repeat.
  
• PP2C are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways. For details see ABA-regulated Protein Phosphatase 2C.
  
• PP4 regulates a variety of cellular functions.
  
• PP5 is activated by lipids and is involved in signal transduction.

3D Structures of protein phosphatase

Updated on 27-January-2016

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• Protein phosphatase 1A
  • 3fxj, 3fxk, 3fxl, 3fxm, 3fxo, 4ra2 – hPP1A + Mn – human
    
  • 4da1 – hPP1K + Mn
    
  • 3n5u – hPP1A catalytic subunit + retinoblastoma-associated protein
    
  • 3v4y – hPP1A catalytic subunit + PP1 nuclear inhibitor
    
  • 4g9j – hPP1A catalytic subunit + peptide
    
  • 2rlt – PP1 regulatory subunit – pig - NMR
    
• Protein phosphatase 2A
  • 1b3u, 2g62 – hPP2A regulatory subunit
    
  • 2ie3, 2ie4, 2npp, 2nyl, 2nym – hPP2A catalytic + regulatory subunit + tumor-inducing toxin
    
  • 3c5w – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase
    
• Protein phosphatase 2C
  • 2iq1 – hPP2C κ
    
  • 3d8k – PP2C – Toxoplasma gondii
    
  • 3jrq, 3nmn – AtPP2C + Pyl1 – Arabidopsis thaliana
    
  • 3nmt, 3kb3, 3nmv, 3ujl – AtPP2C + Pyl2
    
  • 4la7, 4lg5, [4lga]], 4lgb – AtPP2C + Pyl2 + ligand
    
  • 4ds8 – AtPP2C + Pyl3 + Mn
    
  • 3rt0 – AtPP2C (mutant) + Pyl10
    
  • 4n0g – AtPP2C + Pyl13
    
  • 3qn1, 3zvu, 4wvo – AtPP2C + Pyr1
    
  • 3ujk – AtPP2C
    
  • 4yzg – AtPP2C (mutant)
    
  • 4yzh – AtPP2C (mutant) + chlorophyll-binding protein peptide
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Alexsandra Tifane Santos do Nascimento, Joel L. Sussman