Pyruvate dehydrogenase: Difference between revisions
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{{STRUCTURE_1l8a| PDB=1l8a | SIZE=400| SCENE= |right|CAPTION= E. coli pyruvate dehydrogenase dimer complex with thiamine diphosphate and Mg+2 ion (green), [[1l8a]] }} | {{STRUCTURE_1l8a| PDB=1l8a | SIZE=400| SCENE= |right|CAPTION= E. coli pyruvate dehydrogenase dimer complex with thiamine diphosphate and Mg+2 ion (green), [[1l8a]] }} | ||
==Function== | |||
'''Pyruvate dehydrogenase''' (E1) is one of three main components of the multienzyme complex pyruvate dehydrogenase. It accompanies dihydrolipoyl transacetylase (E2) and dihydrolipoyl dehydrogenase (E3) in comprising this multienzyme complex. The ''E. coli'' enzyme complex has a weight of approximately 4600-kD and a diameter of about 300 angstroms. The core of the particle is made of 24 E2 proteins arranged in a cube, which is surrounded by 24 E1 proteins and 12 E3 proteins. Together, these enzymes are responsible for synthesizing acetyl-CoA from pyruvate just prior to entrance into the citric acid cycle. Therefore, pyruvate dehydrogenase contributes to linking the glycolysis metabolic pathway to the citric acid pathway. For more details on E3 see [[Dihydrolipoamide dehydrogenase]]. | '''Pyruvate dehydrogenase''' (E1) is one of three main components of the multienzyme complex pyruvate dehydrogenase. It accompanies dihydrolipoyl transacetylase (E2) and dihydrolipoyl dehydrogenase (E3) in comprising this multienzyme complex. The ''E. coli'' enzyme complex has a weight of approximately 4600-kD and a diameter of about 300 angstroms. The core of the particle is made of 24 E2 proteins arranged in a cube, which is surrounded by 24 E1 proteins and 12 E3 proteins. Together, these enzymes are responsible for synthesizing acetyl-CoA from pyruvate just prior to entrance into the citric acid cycle. Therefore, pyruvate dehydrogenase contributes to linking the glycolysis metabolic pathway to the citric acid pathway. For more details on E3 see [[Dihydrolipoamide dehydrogenase]]. | ||
See also [[Pyruvate Dehydrogenase (Hebrew)]]. | |||
==Structure== | ==Structure== | ||
