5bnv: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer==

~~The entry~~ 5bnv is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5bnv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNV OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BNV FirstGlance].

~~Authors~~: ~~Huang~~, H., ~~Patel, D~~.J.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5bnx|5bnx]], [[5bo0|5bo0]]</td></tr>

~~Description: Crystal structure of Human MCM2 HBD chaperoning a histone H3~~-~~H4 tetramer~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bnv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bnv RCSB], [http://www.ebi.ac.uk/pdbsum/5bnv PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures]~~]

</table>

[[~~Category~~: ~~Patel, D~~.J]]

== Function ==

[[http://www.uniprot.org/uniprot/MCM2_HUMAN MCM2_HUMAN]] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.<ref>PMID:8175912</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Huang, H]]

[[Category: Patel, D J]]

[[Category: Chaperone-dna binding protein complex]]

[[Category: Dna replication]]

[[Category: H3-h4 tetramer]]

[[Category: Histone chaperone]]

[[Category: Mcm2 helicase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer==
+<StructureSection load='5bnv' size='340' side='right' caption='[[5bnv]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
-The entry 5bnv is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5bnv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BNV FirstGlance]. <br>
-Authors: Huang, H., Patel, D.J.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bnx|5bnx]], [[5bo0|5bo0]]</td></tr>
-Description: Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bnv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bnv RCSB], [http://www.ebi.ac.uk/pdbsum/5bnv PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Patel, D.J]]
+== Function ==
+[[http://www.uniprot.org/uniprot/MCM2_HUMAN MCM2_HUMAN]] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.<ref>PMID:8175912</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Huang, H]]
+[[Category: Patel, D J]]
+[[Category: Chaperone-dna binding protein complex]]
+[[Category: Dna replication]]
+[[Category: H3-h4 tetramer]]
+[[Category: Histone chaperone]]
+[[Category: Mcm2 helicase]]