5bo0: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.2-H4 dimer==

~~The entry~~ 5bo0 is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5bo0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BO0 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BO0 FirstGlance].

~~Authors~~: ~~Huang~~, H., ~~Patel~~, D.J.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5bnv|5bnv]], [[5bnx|5bnx]]</td></tr>

~~Description~~: ~~Crystal structure of Human MCM2 HBD~~ and ~~ASF1b chaperoning a~~ histone H3.2-~~H4 dimer~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bo0 RCSB], [http://www.ebi.ac.uk/pdbsum/5bo0 PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

~~[[Category: Patel~~, D.~~J]]~~

== Function ==

[[http://www.uniprot.org/uniprot/ASF1B_HUMAN ASF1B_HUMAN]] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.<ref>PMID:11897662</ref> <ref>PMID:12842904</ref> <ref>PMID:14718166</ref> <ref>PMID:15664198</ref> <ref>PMID:16151251</ref> [[http://www.uniprot.org/uniprot/MCM2_HUMAN MCM2_HUMAN]] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.<ref>PMID:8175912</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Huang, H]]

[[Category: Patel, D J]]

[[Category: Asf1b]]

[[Category: Chaperone-dna binding protein complex]]

[[Category: Dna replication]]

[[Category: H3 2-h4 dimer]]

[[Category: Mcm2]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.2-H4 dimer==
+<StructureSection load='5bo0' size='340' side='right' caption='[[5bo0]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
-The entry 5bo0 is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5bo0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BO0 FirstGlance]. <br>
-Authors: Huang, H., Patel, D.J.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bnv|5bnv]], [[5bnx|5bnx]]</td></tr>
-Description: Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.2-H4 dimer
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bo0 RCSB], [http://www.ebi.ac.uk/pdbsum/5bo0 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Patel, D.J]]
+== Function ==
+[[http://www.uniprot.org/uniprot/ASF1B_HUMAN ASF1B_HUMAN]] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.<ref>PMID:11897662</ref> <ref>PMID:12842904</ref> <ref>PMID:14718166</ref> <ref>PMID:15664198</ref> <ref>PMID:16151251</ref>  [[http://www.uniprot.org/uniprot/MCM2_HUMAN MCM2_HUMAN]] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.<ref>PMID:8175912</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Huang, H]]
+[[Category: Patel, D J]]
+[[Category: Asf1b]]
+[[Category: Chaperone-dna binding protein complex]]
+[[Category: Dna replication]]
+[[Category: H3 2-h4 dimer]]
+[[Category: Mcm2]]