5bpu: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I==

~~The entry~~ 5bpu is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPU FirstGlance].

~~Authors~~: ~~Chang, T~~.-H., ~~Hsieh~~, F.-L., ~~Harlos, K~~.~~, Jones, E~~.Y.

</td></tr><tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4my2|4my2]]</td></tr>

~~Description~~:

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [http://www.ebi.ac.uk/pdbsum/5bpu PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

[[Category: ~~Hsieh~~, ~~F.-L~~]]

== Disease ==

[[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Coats disease;Persistent hyperplastic primary vitreous;Norrie disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

__TOC__

</StructureSection>

[[Category: Chang, T H]]

[[Category: Harlos, K]]

[[Category: Jones, E.Y]]

[[Category: Hsieh, F L]]

[[Category: ~~Chang, T.~~-H]]

[[Category: Jones, E Y]]

[[Category: Cystine-knot like growth factor]]

[[Category: Ligand for frizzled 4 receptor]]

[[Category: Norrie disease protein]]

[[Category: Signaling protein]]

[[Category: Wnt signalling pathway]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I==
+<StructureSection load='5bpu' size='340' side='right' caption='[[5bpu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-The entry 5bpu is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5bpu]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPU FirstGlance]. <br>
-Authors: Chang, T.-H., Hsieh, F.-L., Harlos, K., Jones, E.Y.
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4my2|4my2]]</td></tr>
-Description:
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bpu RCSB], [http://www.ebi.ac.uk/pdbsum/5bpu PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Hsieh, F.-L]]
+== Disease ==
+[[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Coats disease;Persistent hyperplastic primary vitreous;Norrie disease. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN]] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
+__TOC__
+</StructureSection>
+[[Category: Chang, T H]]
 [[Category: Harlos, K]]
-[[Category: Jones, E.Y]]
+[[Category: Hsieh, F L]]
-[[Category: Chang, T.-H]]
+[[Category: Jones, E Y]]
+[[Category: Cystine-knot like growth factor]]
+[[Category: Ligand for frizzled 4 receptor]]
+[[Category: Norrie disease protein]]
+[[Category: Signaling protein]]
+[[Category: Wnt signalling pathway]]