4z2b: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==The structure of human PDE12 residues 161-609 in complex with GSK3036342A==

~~The entry~~ 4z2b is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4z2b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2B OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2B FirstGlance].

~~Authors~~: ~~Nolte~~, R.T., ~~Wisely, B~~., ~~Wang, L~~.~~, Wood, E~~.R.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=4LC:3-(6-{[(2S,3S)-3-(HYDROXYMETHYL)-2-PHENYLMORPHOLIN-4-YL]CARBONYL}-1-METHYL-1H-BENZIMIDAZOL-2-YL)-1H-INDOLE-6-CARBONITRILE'>4LC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4z0v|4z0v]]</td></tr>

~~Description: The structure of human PDE12 residues 161-609 in complex with GSK3036342A~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4z2b RCSB], [http://www.ebi.ac.uk/pdbsum/4z2b PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

[[Category: ~~Wood~~, E.R]]

== Function ==

[[http://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Nolte, R T]]

[[Category: Wang, L]]

[[Category: Wisely, B]]

[[Category: ~~Nolte~~, R.T]]

[[Category: Wood, E R]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Pde12 2'-5'a eep nuclease inhibitor complex]]

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-'''Unreleased structure'''
+==The structure of human PDE12 residues 161-609 in complex with GSK3036342A==
+<StructureSection load='4z2b' size='340' side='right' caption='[[4z2b]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-The entry 4z2b is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4z2b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2B FirstGlance]. <br>
-Authors: Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4LC:3-(6-{[(2S,3S)-3-(HYDROXYMETHYL)-2-PHENYLMORPHOLIN-4-YL]CARBONYL}-1-METHYL-1H-BENZIMIDAZOL-2-YL)-1H-INDOLE-6-CARBONITRILE'>4LC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4z0v|4z0v]]</td></tr>
-Description: The structure of human PDE12 residues 161-609 in complex with GSK3036342A
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4z2b RCSB], [http://www.ebi.ac.uk/pdbsum/4z2b PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Wood, E.R]]
+== Function ==
+[[http://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Nolte, R T]]
 [[Category: Wang, L]]
 [[Category: Wisely, B]]
-[[Category: Nolte, R.T]]
+[[Category: Wood, E R]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Pde12 2'-5'a eep nuclease inhibitor complex]]