5bpb: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form I==

~~The entry~~ 5bpb is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5bpb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPB FirstGlance]. <br>

~~Authors~~: ~~Chang, T~~.-H., ~~Hsieh~~, F.-L., ~~Harlos, K~~.~~, Jones, E~~.Y.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bpb RCSB], [http://www.ebi.ac.uk/pdbsum/5bpb PDBsum]</span></td></tr>

~~Description~~:

</table>

[[~~Category~~: ~~Unreleased Structures~~]]

== Disease ==

[[Category: ~~Hsieh~~, ~~F.-L~~]]

[[http://www.uniprot.org/uniprot/FZD4_HUMAN FZD4_HUMAN]] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Persistent hyperplastic primary vitreous. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/FZD4_HUMAN FZD4_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

__TOC__

</StructureSection>

[[Category: Chang, T H]]

[[Category: Harlos, K]]

[[Category: Jones, E.Y]]

[[Category: Hsieh, F L]]

[[Category: ~~Chang, T.-H~~]]

[[Category: Jones, E Y]]

[[Category: G protein coupled receptor]]

[[Category: Glycoprotein]]

[[Category: Receptor for norrin recognition]]

[[Category: Signaling protein]]

[[Category: Wnt signalling pathway]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of the cysteine-rich domain of human Frizzled 4 - Crystal Form I==
+<StructureSection load='5bpb' size='340' side='right' caption='[[5bpb]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-The entry 5bpb is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5bpb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BPB FirstGlance]. <br>
-Authors: Chang, T.-H., Hsieh, F.-L., Harlos, K., Jones, E.Y.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bpb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bpb RCSB], [http://www.ebi.ac.uk/pdbsum/5bpb PDBsum]</span></td></tr>
-Description:
+</table>
-[[Category: Unreleased Structures]]
+== Disease ==
-[[Category: Hsieh, F.-L]]
+[[http://www.uniprot.org/uniprot/FZD4_HUMAN FZD4_HUMAN]] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Persistent hyperplastic primary vitreous. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/FZD4_HUMAN FZD4_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
+__TOC__
+</StructureSection>
+[[Category: Chang, T H]]
 [[Category: Harlos, K]]
-[[Category: Jones, E.Y]]
+[[Category: Hsieh, F L]]
-[[Category: Chang, T.-H]]
+[[Category: Jones, E Y]]
+[[Category: G protein coupled receptor]]
+[[Category: Glycoprotein]]
+[[Category: Receptor for norrin recognition]]
+[[Category: Signaling protein]]
+[[Category: Wnt signalling pathway]]