5bqx: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of human STING in complex with 3'2'-cGAMP==

~~The entry~~ 5bqx is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5bqx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQX OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQX FirstGlance].

~~Authors~~: Wu, J., ~~Zhang, X~~., ~~Chen, Z~~.J.~~, Chen, C~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=4UR:32-CGAMP'>4UR</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4ksy|4ksy]]</td></tr>

~~Description~~: ~~Crystal structure~~ of ~~human~~ STING in complex ~~with 3'2'~~-~~cGAMP~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bqx RCSB], [http://www.ebi.ac.uk/pdbsum/5bqx PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Chen, C]]

[[Category: Chen, Z J]]

[[Category: Wu, J]]

[[Category: Zhang, X]]

[[Category: ~~Wu, J~~]]

[[Category: 3'2'-cgamp]]

[[Category: ~~Chen, Z.J~~]]

[[Category: Immune system]]

[[Category: ~~Chen, C~~]]

[[Category: Sting]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of human STING in complex with 3'2'-cGAMP==
+<StructureSection load='5bqx' size='340' side='right' caption='[[5bqx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-The entry 5bqx is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5bqx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BQX FirstGlance]. <br>
-Authors: Wu, J., Zhang, X., Chen, Z.J., Chen, C.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4UR:32-CGAMP'>4UR</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ksy|4ksy]]</td></tr>
-Description: Crystal structure of human STING in complex with 3'2'-cGAMP
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bqx RCSB], [http://www.ebi.ac.uk/pdbsum/5bqx PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chen, C]]
+[[Category: Chen, Z J]]
+[[Category: Wu, J]]
 [[Category: Zhang, X]]
-[[Category: Wu, J]]
+[[Category: 3'2'-cgamp]]
-[[Category: Chen, Z.J]]
+[[Category: Immune system]]
-[[Category: Chen, C]]
+[[Category: Sting]]