5bt5: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe==

~~The entry~~ 5bt5 is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5bt5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BT5 FirstGlance]. <br>

~~Authors~~: ~~Tallant~~, C., ~~Hay~~, D., ~~Krojer, T~~.~~, Nunez~~-~~Alonso~~, G.~~, Picaud, S~~., ~~Newman, J~~.A.~~, Fedorov, O~~.~~, von Delft, F~~.~~, Arrowsmith, C~~.H., ~~Edwards, A~~.M., Bountra, C., Brennan, P.E~~., Knapp, S., Structural Genomics Consortium (SGC)~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LO:2-[2-(3-CHLORO-4-METHOXYPHENYL)ETHYL]-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-1-[(2S)-2-(MORPHOLIN-4-YL)PROPYL]-1H-BENZIMIDAZOLE'>2LO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bt5 RCSB], [http://www.ebi.ac.uk/pdbsum/5bt5 PDBsum]</span></td></tr>

~~Description: Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe~~

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[Category: ~~Nunez-Alonso~~, G]]

[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Brennan, P E]]

[[Category: Delft, F von]]

[[Category: Edwards, A M]]

[[Category: Fedorov, O]]

[[Category: ~~Picaud~~, S]]

[[Category: Hay, D]]

[[Category: Knapp, S]]

~~[[Category: Hay, D]]~~

[[Category: Krojer, T]]

[[Category: ~~Bountra, C]]~~

[[Category: Newman, J A]]

~~[[Category: Arrowsmith, C.H]]~~

[[Category: Nunez-Alonso, G]]

~~[[Category: Von Delft, F]]~~

[[Category: Picaud, S]]

~~[[Category: Edwards~~, A.M]]

[[Category: Structural genomic]]

[[Category: ~~Brennan~~, ~~P.E~~]]

[[Category: ~~Newman~~, ~~J.A~~]]

[[Category: Structural ~~Genomics Consortium (Sgc)~~]]

[[Category: Tallant, C]]

[[Category: Acetylation]]

[[Category: Chromatin and transcription regulator]]

[[Category: Sgc]]

[[Category: Transcription]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe==
+<StructureSection load='5bt5' size='340' side='right' caption='[[5bt5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-The entry 5bt5 is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5bt5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BT5 FirstGlance]. <br>
-Authors: Tallant, C., Hay, D., Krojer, T., Nunez-Alonso, G., Picaud, S., Newman, J.A., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LO:2-[2-(3-CHLORO-4-METHOXYPHENYL)ETHYL]-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-1-[(2S)-2-(MORPHOLIN-4-YL)PROPYL]-1H-BENZIMIDAZOLE'>2LO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bt5 RCSB], [http://www.ebi.ac.uk/pdbsum/5bt5 PDBsum]</span></td></tr>
-Description: Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Nunez-Alonso, G]]
+[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Brennan, P E]]
+[[Category: Delft, F von]]
+[[Category: Edwards, A M]]
 [[Category: Fedorov, O]]
-[[Category: Picaud, S]]
+[[Category: Hay, D]]
 [[Category: Knapp, S]]
-[[Category: Hay, D]]
 [[Category: Krojer, T]]
-[[Category: Bountra, C]]
+[[Category: Newman, J A]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Nunez-Alonso, G]]
-[[Category: Von Delft, F]]
+[[Category: Picaud, S]]
-[[Category: Edwards, A.M]]
+[[Category: Structural genomic]]
-[[Category: Brennan, P.E]]
-[[Category: Newman, J.A]]
-[[Category: Structural Genomics Consortium (Sgc)]]
 [[Category: Tallant, C]]
+[[Category: Acetylation]]
+[[Category: Chromatin and transcription regulator]]
+[[Category: Sgc]]
+[[Category: Transcription]]