5a2p: Difference between revisions
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==THE COMPLEX STRUCTURE OF PDZ DOMAINS IN SYNTENIN-1 WITH 4L PEPTIDE== | |||
<StructureSection load='5a2p' size='340' side='right' caption='[[5a2p]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5a2p]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A2P FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2p OCA], [http://pdbe.org/5a2p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a2p RCSB], [http://www.ebi.ac.uk/pdbsum/5a2p PDBsum]</span></td></tr> | |||
[[ | </table> | ||
[[ | == Function == | ||
[[Category: Cho, H | [[http://www.uniprot.org/uniprot/SDCB1_RAT SDCB1_RAT]] Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.[UniProtKB:O00560] [[http://www.uniprot.org/uniprot/SDC4_RAT SDC4_RAT]] Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.[UniProtKB:P31431] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cho, H S]] | |||
[[Category: Lee, W]] | [[Category: Lee, W]] | ||
[[Category: Yun, J | [[Category: Yoo, J H]] | ||
[[Category: Yun, J H]] | |||
[[Category: Cell adhesion]] | |||
[[Category: Pdz domain]] | |||
[[Category: Signaling protein]] | |||
[[Category: Syndecan-4]] | |||
[[Category: Syntenin-1]] | |||
Revision as of 06:04, 2 June 2016
THE COMPLEX STRUCTURE OF PDZ DOMAINS IN SYNTENIN-1 WITH 4L PEPTIDE
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