3byz: Difference between revisions

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|PDB= 3byz |SIZE=350|CAPTION= <scene name='initialview01'>3byz</scene>, resolution 2.69&Aring;
|PDB= 3byz |SIZE=350|CAPTION= <scene name='initialview01'>3byz</scene>, resolution 2.69&Aring;
|SITE= <scene name='pdbsite=AC1:Ndp+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Ndp+Binding+Site+For+Residue+B+502'>AC2</scene>, <scene name='pdbsite=AC3:Ndp+Binding+Site+For+Residue+C+503'>AC3</scene>, <scene name='pdbsite=AC4:Ndp+Binding+Site+For+Residue+D+504'>AC4</scene>, <scene name='pdbsite=AC5:H11+Binding+Site+For+Residue+A+601'>AC5</scene>, <scene name='pdbsite=AC6:H11+Binding+Site+For+Residue+B+602'>AC6</scene>, <scene name='pdbsite=AC7:H11+Binding+Site+For+Residue+D+603'>AC7</scene> and <scene name='pdbsite=AC8:H11+Binding+Site+For+Residue+C+604'>AC8</scene>
|SITE= <scene name='pdbsite=AC1:Ndp+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Ndp+Binding+Site+For+Residue+B+502'>AC2</scene>, <scene name='pdbsite=AC3:Ndp+Binding+Site+For+Residue+C+503'>AC3</scene>, <scene name='pdbsite=AC4:Ndp+Binding+Site+For+Residue+D+504'>AC4</scene>, <scene name='pdbsite=AC5:H11+Binding+Site+For+Residue+A+601'>AC5</scene>, <scene name='pdbsite=AC6:H11+Binding+Site+For+Residue+B+602'>AC6</scene>, <scene name='pdbsite=AC7:H11+Binding+Site+For+Residue+D+603'>AC7</scene> and <scene name='pdbsite=AC8:H11+Binding+Site+For+Residue+C+604'>AC8</scene>
|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=H11:'>H11</scene>
|LIGAND= <scene name='pdbligand=H11:(5S)-2-(CYCLOOCTYLAMINO)-5-METHYL-5-PROPYL-1,3-THIAZOL-4(5H)-ONE'>H11</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146]  
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span>
|GENE= HSD11B1, HSD11, HSD11L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= HSD11B1, HSD11, HSD11L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|DOMAIN=
|RELATEDENTRY=[[2rbe|2RBE]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3byz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3byz OCA], [http://www.ebi.ac.uk/pdbsum/3byz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3byz RCSB]</span>
}}
}}


Line 20: Line 23:
[[Category: Li, V.]]
[[Category: Li, V.]]
[[Category: Zhang, J.]]
[[Category: Zhang, J.]]
[[Category: H11]]
[[Category: NDP]]
[[Category: 3-layer (aba) sandwich]]
[[Category: 3-layer (aba) sandwich]]
[[Category: alpha beta]]
[[Category: alpha beta]]
Line 38: Line 39:
[[Category: transmembrane]]
[[Category: transmembrane]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:01:51 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:29:46 2008''

Revision as of 02:29, 31 March 2008

File:3byz.jpg


Drag the structure with the mouse to rotate
3byz, resolution 2.69Å
Sites: AC1, AC2, AC3, AC4, AC5, AC6, AC7 and AC8
Ligands: H11, NDP
Gene: HSD11B1, HSD11, HSD11L (Homo sapiens)
Activity: 11-beta-hydroxysteroid dehydrogenase, with EC number 1.1.1.146
Related: 2RBE


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors


About this Structure

3BYZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Mon Mar 31 05:29:46 2008

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