Tryptase: Difference between revisions
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{{STRUCTURE_2zeb| PDB=2zeb | SIZE=400| SCENE= |right|CAPTION=Human tryptase β-2 tetramer complex with piperidine derivative inhibitor, [[2zeb]] }} | {{STRUCTURE_2zeb| PDB=2zeb | SIZE=400| SCENE= |right|CAPTION=Human tryptase β-2 tetramer complex with piperidine derivative inhibitor, [[2zeb]] }} | ||
== Function == | |||
'''Tryptase''' (TRP) is a serine protease found in mast cells<ref>PMID:15200544</ref>. | |||
== Relevance == | |||
TRP is used as a marker for mast cell activation<ref>PMID:1607547</ref>. Inhibitors of TRP have therapeutic potential for treating allergic or inflammatory disorders such as asthma and inflammatory bowel diseases<ref>PMID:16640553</ref>. | |||
== Structural highlights == | |||
The piperidine derivative TRP inhibitor interacts with both subunits of TRP<ref>PMID:18272363</ref>. | |||
== 3D Structures of tryptase == | == 3D Structures of tryptase == | ||
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**[[3v7t]] - hTRP-β2 + tropanylamide inhibitor<br /> | **[[3v7t]] - hTRP-β2 + tropanylamide inhibitor<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
