5bxt: Difference between revisions
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''' | ==LNBase in complex with LNB-NHAcAUS== | ||
<StructureSection load='5bxt' size='340' side='right' caption='[[5bxt]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5bxt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BXT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WS:N-{[(1R,2R,3R,7S,7AR)-1,2,7-TRIHYDROXYHEXAHYDRO-1H-PYRROLIZIN-3-YL]METHYL}ACETAMIDE'>4WS</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bxp|5bxp]], [[5bxs|5bxs]], [[5bxr|5bxr]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lacto-N-biosidase Lacto-N-biosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.140 3.2.1.140] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bxt RCSB], [http://www.ebi.ac.uk/pdbsum/5bxt PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The synthesis of potent inhibitors for lacto-N-biosidases and X-ray structural characterization of these compounds in complex with BbLNBase is described. | |||
Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis.,Hattie M, Ito T, Debowski AW, Arakawa T, Katayama T, Yamamoto K, Fushinobu S, Stubbs KA Chem Commun (Camb). 2015 Aug 27. PMID:26312778<ref>PMID:26312778</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Lacto-N-biosidase]] | |||
[[Category: Arakawa, T]] | |||
[[Category: Fushinobu, S]] | [[Category: Fushinobu, S]] | ||
[[Category: Ito, T]] | [[Category: Ito, T]] | ||
[[Category: | [[Category: Distal gut]] | ||
[[Category: Human milk oligosaccharide]] | |||
[[Category: Hydrolase]] | |||
[[Category: Inhibitor]] | |||
[[Category: Tim barrel]] | |||
Revision as of 11:09, 9 September 2015
LNBase in complex with LNB-NHAcAUS
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