5bya: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PCP)2-IP4==

~~The entry~~ 5bya is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5bya]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BYA OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BYA FirstGlance].

~~Authors~~: ~~Wang~~, H., ~~Shears~~, S.B.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=4WZ:{[(1R,3S,4S,5R,6S)-2,4,5,6-TETRAKIS(PHOSPHONOOXY)CYCLOHEXANE-1,3-DIYL]BIS[OXY(HYDROXYPHOSPHORYL)METHANEDIYL]}BIS(PHOSPHONIC+ACID)'>4WZ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5byb|5byb]]</td></tr>

~~Description~~: ~~Crystal structure of~~ the ~~catalytic domain of human~~ diphosphoinositol pentakisphosphate ~~kinase~~ 2 (~~PPIP5K2~~) ~~in complex with ADP~~ and 1,5-(PC)2-~~IP4~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bya RCSB], [http://www.ebi.ac.uk/pdbsum/5bya PDBsum]</td></tr>

~~[[Category: Unreleased Structures]]~~

</table>

[[Category: Shears, S.B]]

== Function ==

[[http://www.uniprot.org/uniprot/VIP2_HUMAN VIP2_HUMAN]] Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.<ref>PMID:17690096</ref> <ref>PMID:17702752</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Shears, S B]]

[[Category: Wang, H]]

[[Category: Methylenebisphosphonate]]

[[Category: Non-hydrolyzable]]

[[Category: Phosphonoacetate]]

[[Category: Pyrophosphate mimic]]

[[Category: Transferase]]

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-'''Unreleased structure'''
+==Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PCP)2-IP4==
+<StructureSection load='5bya' size='340' side='right' caption='[[5bya]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-The entry 5bya is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5bya]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BYA FirstGlance]. <br>
-Authors: Wang, H., Shears, S.B.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WZ:{[(1R,3S,4S,5R,6S)-2,4,5,6-TETRAKIS(PHOSPHONOOXY)CYCLOHEXANE-1,3-DIYL]BIS[OXY(HYDROXYPHOSPHORYL)METHANEDIYL]}BIS(PHOSPHONIC+ACID)'>4WZ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5byb|5byb]]</td></tr>
-Description: Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PC)2-IP4
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bya RCSB], [http://www.ebi.ac.uk/pdbsum/5bya PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Shears, S.B]]
+== Function ==
+[[http://www.uniprot.org/uniprot/VIP2_HUMAN VIP2_HUMAN]] Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.<ref>PMID:17690096</ref> <ref>PMID:17702752</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Shears, S B]]
 [[Category: Wang, H]]
+[[Category: Methylenebisphosphonate]]
+[[Category: Non-hydrolyzable]]
+[[Category: Phosphonoacetate]]
+[[Category: Pyrophosphate mimic]]
+[[Category: Transferase]]