2n07: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 2n07 is ~~ON HOLD until Paper Publication~~

==Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1==

~~Authors~~: Yu, R., ~~Seymour~~, V., ~~Berecki~~, G., ~~Jia, X~~.~~, Akcan, M~~., ~~Adams, D~~., ~~Kaas, Q~~., ~~Craik~~, D.

== Structural highlights ==

<table><tr><td colspan='2'>[[2n07]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N07 FirstGlance]. <br>

~~Description: Design of a Highly Stable Disulfide~~-~~Deleted Mutant of Analgesic Cyclic~~ alpha-~~Conotoxin Vc1~~.1

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n07 OCA], [http://pdbe.org/2n07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n07 RCSB], [http://www.ebi.ac.uk/pdbsum/2n07 PDBsum]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

[[Category: ~~Jia~~, X]]

== Function ==

[[http://www.uniprot.org/uniprot/CA1A_CONVC CA1A_CONVC]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This synthetic peptide (produced without hydroxyproline, nor 4-carboxyglutamate) is a neuronal nAChR antagonist that acts as a powerful analgesic. It blocks nAChRs composed of alpha-3 or -5/beta-2 (IC(50)=7.2 uM), alpha-3/beta-2 (IC(50)=7.3 uM), alpha-3/beta-4 (IC(50)=4.2 uM), alpha-3 or -5/beta-4 (IC(50)<30 uM), alpha-4/beta-2 (IC(50)<30 uM), alpha-4/beta-4 (IC(50)<30 uM) and alpha/beta/gamma/delta (IC(50)<30 uM) subunits.<ref>PMID:12779345</ref> <ref>PMID:15770155</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Adams, D]]

[[Category: Akcan, M]]

[[Category: Berecki, G]]

[[Category: Craik, D]]

[[Category: Jia, X]]

[[Category: Kaas, Q]]

[[Category: Seymour, V]]

[[Category: Yu, R]]

[[Category: ~~Akcan, M~~]]

[[Category: Cvc1 1]]

[[Category: ~~Adams, D~~]]

[[Category: Disulfide-deleted mutant]]

[[Category: ~~Seymour, V~~]]

[[Category: Toxin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 2n07 is ON HOLD  until Paper Publication
+==Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1==
+<StructureSection load='2n07' size='340' side='right' caption='[[2n07]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-Authors: Yu, R., Seymour, V., Berecki, G., Jia, X., Akcan, M., Adams, D., Kaas, Q., Craik, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2n07]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N07 FirstGlance]. <br>
-Description: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n07 OCA], [http://pdbe.org/2n07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n07 RCSB], [http://www.ebi.ac.uk/pdbsum/2n07 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Jia, X]]
+== Function ==
+[[http://www.uniprot.org/uniprot/CA1A_CONVC CA1A_CONVC]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This synthetic peptide (produced without hydroxyproline, nor 4-carboxyglutamate) is a neuronal nAChR antagonist that acts as a powerful analgesic. It blocks nAChRs composed of alpha-3 or -5/beta-2 (IC(50)=7.2 uM), alpha-3/beta-2 (IC(50)=7.3 uM), alpha-3/beta-4 (IC(50)=4.2 uM), alpha-3 or -5/beta-4 (IC(50)<30 uM), alpha-4/beta-2 (IC(50)<30 uM), alpha-4/beta-4 (IC(50)<30 uM) and alpha/beta/gamma/delta (IC(50)<30 uM) subunits.<ref>PMID:12779345</ref> <ref>PMID:15770155</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Adams, D]]
+[[Category: Akcan, M]]
 [[Category: Berecki, G]]
 [[Category: Craik, D]]
+[[Category: Jia, X]]
 [[Category: Kaas, Q]]
+[[Category: Seymour, V]]
 [[Category: Yu, R]]
-[[Category: Akcan, M]]
+[[Category: Cvc1 1]]
-[[Category: Adams, D]]
+[[Category: Disulfide-deleted mutant]]
-[[Category: Seymour, V]]
+[[Category: Toxin]]