2n3o: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The~~ entry 2n3o is ~~ON HOLD until Paper Publication~~

==Structure of PTB RRM1(41-163) bound to an RNA stemloop containing a structured loop derived from viral internal ribosomal entry site RNA==

~~Authors~~: ~~Maris~~, C., ~~Jayne~~, S.F., ~~Damberger, F~~.F.~~, Ravindranathan, S~~., ~~Allain, F.H~~.-T.

== Structural highlights ==

<table><tr><td colspan='2'>[[2n3o]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N3O FirstGlance]. <br>

~~Description~~: ~~Structure~~ of ~~PTB RRM1(41~~-~~163)~~ bound to ~~an RNA stemloop containing a structured loop derived from viral internal ribosomal entry site RNA~~

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ad9|2ad9]], [[1sjq|1sjq]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3o OCA], [http://pdbe.org/2n3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n3o RCSB], [http://www.ebi.ac.uk/pdbsum/2n3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3o ProSAT]</span></td></tr>

[[Category: Jayne, S.F]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN]] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Allain, F H.T]]

[[Category: Damberger, F F]]

[[Category: Jayne, S F]]

[[Category: Maris, C]]

[[Category: Ravindranathan, S]]

[[Category: ~~Allain, F.H.~~-T]]

[[Category: C-terminal helix formation]]

[[Category: ~~Damberger, F.F~~]]

[[Category: Ire]]

[[Category: ~~Maris, C~~]]

[[Category: Polypyirimine tract binding protein]]

[[Category: Ptb]]

[[Category: Rna binding protein-rna complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 2n3o is ON HOLD  until Paper Publication
+==Structure of PTB RRM1(41-163) bound to an RNA stemloop containing a structured loop derived from viral internal ribosomal entry site RNA==
+<StructureSection load='2n3o' size='340' side='right' caption='[[2n3o]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-Authors: Maris, C., Jayne, S.F., Damberger, F.F., Ravindranathan, S., Allain, F.H.-T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2n3o]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N3O FirstGlance]. <br>
-Description: Structure of PTB RRM1(41-163) bound to an RNA stemloop containing a structured loop derived from viral internal ribosomal entry site RNA
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ad9|2ad9]], [[1sjq|1sjq]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3o OCA], [http://pdbe.org/2n3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n3o RCSB], [http://www.ebi.ac.uk/pdbsum/2n3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3o ProSAT]</span></td></tr>
-[[Category: Jayne, S.F]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN]] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Allain, F H.T]]
+[[Category: Damberger, F F]]
+[[Category: Jayne, S F]]
+[[Category: Maris, C]]
 [[Category: Ravindranathan, S]]
-[[Category: Allain, F.H.-T]]
+[[Category: C-terminal helix formation]]
-[[Category: Damberger, F.F]]
+[[Category: Ire]]
-[[Category: Maris, C]]
+[[Category: Polypyirimine tract binding protein]]
+[[Category: Ptb]]
+[[Category: Rna binding protein-rna complex]]