P63: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='3us0' size='340' side='right' caption='P63 DNA-binding domain complex with DNA (PDB code 3us0)' scene=''> '''P63''' is a tumor protein belonging to the P53 fam... |
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<StructureSection load='3us0' size='340' side='right' caption='P63 DNA-binding domain complex with DNA and Zn+2 atoms (grey) (PDB code [[3us0]])' scene=''> | |||
<StructureSection load='3us0' size='340' side='right' caption='P63 DNA-binding domain complex with DNA (PDB code [[3us0]])' scene=''> | |||
'''P63''' is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development. One isoform of P63 is involved in skin development and stem/progenitor cell regulation. Another isoform functions in apoptosis. P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions. | '''P63''' is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development. One isoform of P63 is involved in skin development and stem/progenitor cell regulation. Another isoform functions in apoptosis. P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions. | ||
