4pf9: Difference between revisions
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==Crystal structure of insulin degrading enzyme complexed with inhibitor== | ==Crystal structure of insulin degrading enzyme complexed with inhibitor== | ||
<StructureSection load='4pf9' size='340' side='right' caption='[[4pf9]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4pf9' size='340' side='right'caption='[[4pf9]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4pf9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PF9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4pf9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PF9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2Q6:METHYL+[(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-AMINO-2-OXOPIPERIDIN-1-YL]-2-CYCLOHEXYLACETYL}AMINO)PHENYL]PENTYL}OXY)PHENYL]-3-(QUINOLIN-3-YL)PROPYL]CARBAMATE'>2Q6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2Q6:METHYL+[(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-AMINO-2-OXOPIPERIDIN-1-YL]-2-CYCLOHEXYLACETYL}AMINO)PHENYL]PENTYL}OXY)PHENYL]-3-(QUINOLIN-3-YL)PROPYL]CARBAMATE'>2Q6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pes|4pes]], [[4pf7|4pf7]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pes|4pes]], [[4pf7|4pf7]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IDE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pf9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pf9 RCSB], [http://www.ebi.ac.uk/pdbsum/4pf9 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pf9 OCA], [http://pdbe.org/4pf9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pf9 RCSB], [http://www.ebi.ac.uk/pdbsum/4pf9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pf9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4pf9" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Insulysin]] | [[Category: Insulysin]] | ||
[[Category: Large Structures]] | |||
[[Category: Guo, S]] | [[Category: Guo, S]] | ||
[[Category: Wang, Y]] | [[Category: Wang, Y]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
