4yia: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4yia is ~~ON HOLD until Mar 01 2017~~

==Structural mechanism of hormone release in thyroxine binding globulin==

~~Authors~~: ~~Zheng~~, Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[4yia]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YIA FirstGlance]. <br>

~~Description~~: ~~Strutural mechanism~~ of ~~hormone in~~ thyroxine binding globulin

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMN:INDOMETHACIN'>IMN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yia OCA], [http://pdbe.org/4yia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yia RCSB], [http://www.ebi.ac.uk/pdbsum/4yia PDBsum]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:[http://omim.org/entry/314200 314200]]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.

== Function ==

[[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Major thyroid hormone transport protein in serum.

__TOC__

</StructureSection>

[[Category: Zheng, Y]]

[[Category: Cation pi interaction]]

[[Category: Hormone release]]

[[Category: Serpin]]

[[Category: Signaling protein]]

[[Category: Thyroxine]]

[[Category: Thyroxine binding globulin]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4yia is ON HOLD  until Mar 01 2017
+==Structural mechanism of hormone release in thyroxine binding globulin==
+<StructureSection load='4yia' size='340' side='right' caption='[[4yia]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
-Authors: Zheng, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4yia]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YIA FirstGlance]. <br>
-Description: Strutural mechanism of hormone in thyroxine binding globulin
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMN:INDOMETHACIN'>IMN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yia OCA], [http://pdbe.org/4yia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yia RCSB], [http://www.ebi.ac.uk/pdbsum/4yia PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:[http://omim.org/entry/314200 314200]]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.
+== Function ==
+[[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Major thyroid hormone transport protein in serum.
+__TOC__
+</StructureSection>
 [[Category: Zheng, Y]]
+[[Category: Cation pi interaction]]
+[[Category: Hormone release]]
+[[Category: Serpin]]
+[[Category: Signaling protein]]
+[[Category: Thyroxine]]
+[[Category: Thyroxine binding globulin]]