5bon: Difference between revisions
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''' | ==Crystal structure of human Nudt15 (MTH2)== | ||
<StructureSection load='5bon' size='340' side='right' caption='[[5bon]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5bon]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BON FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/8-oxo-dGTP_diphosphatase 8-oxo-dGTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.55 3.6.1.55] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bon OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bon RCSB], [http://www.ebi.ac.uk/pdbsum/5bon PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NUD15_HUMAN NUD15_HUMAN]] Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.<ref>PMID:19419956</ref> <ref>PMID:22556419</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: 8-oxo-dGTP diphosphatase]] | |||
[[Category: Carter, M]] | |||
[[Category: Helleday, T]] | [[Category: Helleday, T]] | ||
[[Category: Jemth, A | [[Category: Jemth, A S]] | ||
[[Category: Stenmark, P]] | [[Category: Stenmark, P]] | ||
[[Category: | [[Category: Dimer]] | ||
[[Category: Hydrolase]] | |||
[[Category: Magnesium]] | |||
[[Category: Mth2]] | |||
[[Category: Nucleotide]] | |||
[[Category: Nudix]] | |||
[[Category: Nudt15]] | |||
Revision as of 20:19, 5 August 2015
Crystal structure of human Nudt15 (MTH2)
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