5awm: Difference between revisions

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'''~~Unreleased structure~~'''

==The Crystal Structure of JNK from Drosophila melanogaster Reveals an Evolutionarily Conserved Topology with that of Mammalian JNK Proteins.==

~~The~~ entry ~~5awm~~ is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5awm]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4m3a 4m3a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AWM OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AWM FirstGlance].

~~Authors~~: ~~Boonserm~~, P.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4m3a|4m3a]]</td></tr>

~~Description~~: ~~The Crystal Structure~~ of ~~JNK from Drosophila melanogaster Reveals an Evolutionarily Conserved Topology with that~~ of ~~Mammalian JNK Proteins~~.

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5awm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5awm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5awm RCSB], [http://www.ebi.ac.uk/pdbsum/5awm PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/JNK_DROME JNK_DROME]] Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Controls the expression of a phosphatase, puckered, at the edges of wounded epidermal tissue and in the dorsal epithelium during dorsal closure.<ref>PMID:8946915</ref> <ref>PMID:9224720</ref> <ref>PMID:10433922</ref> <ref>PMID:11784101</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Mitogen-activated protein kinase]]

[[Category: Boonserm, P]]

[[Category: C-jun n-terminal kinase]]

[[Category: Drosophila jnk pathway]]

[[Category: Map kinase]]

[[Category: Transferase]]

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-'''Unreleased structure'''
+==The Crystal Structure of JNK from Drosophila melanogaster Reveals an Evolutionarily Conserved Topology with that of Mammalian JNK Proteins.==
+<StructureSection load='5awm' size='340' side='right' caption='[[5awm]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
-The entry 5awm is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5awm]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4m3a 4m3a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AWM FirstGlance]. <br>
-Authors: Boonserm, P.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m3a|4m3a]]</td></tr>
-Description: The Crystal Structure of JNK from Drosophila melanogaster Reveals an Evolutionarily Conserved Topology with that of Mammalian JNK Proteins.
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5awm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5awm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5awm RCSB], [http://www.ebi.ac.uk/pdbsum/5awm PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/JNK_DROME JNK_DROME]] Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Controls the expression of a phosphatase, puckered, at the edges of wounded epidermal tissue and in the dorsal epithelium during dorsal closure.<ref>PMID:8946915</ref> <ref>PMID:9224720</ref> <ref>PMID:10433922</ref> <ref>PMID:11784101</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Mitogen-activated protein kinase]]
 [[Category: Boonserm, P]]
+[[Category: C-jun n-terminal kinase]]
+[[Category: Drosophila jnk pathway]]
+[[Category: Map kinase]]
+[[Category: Transferase]]